Results 231 to 240 of about 612,123 (266)
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Principles of Molecular Targeting for Radionuclide Therapy
2022Molecular targeting requires assessing several factors that come into play such as the location of the target, the choice of radionuclide, the inertness of the bifunctional chelate and stability of the covalently bound halogens, matching the residence time in the tumor with the physical half-life of the radionuclide, the scale and scope of the disease,
Francesco Bartoli +4 more
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Targeted molecular therapy of malignant gliomas
Current Neurology and Neuroscience Reports, 2005Malignant gliomas are the most common form of primary brain tumors in adults. Despite advances in diagnosis and standard therapies such as surgery, radiation, and chemotherapy, the prognosis remains poor. Recent scientific advances have enhanced our understanding of the biology of gliomas and the role of tyrosine kinase receptors and signal ...
Santosh, Kesari +4 more
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Targets for molecular therapy of skin cancer
Seminars in Cancer Biology, 2004Cancers of the skin encompass the first and second most common neoplasms in the United States, epidermal basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), respectively, as well as the melanocytic malignancy, malignant melanoma (MM). Recently identified alterations in the function of specific genes in these cancers provide new potential ...
Cheryl L, Green, Paul A, Khavari
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2017
Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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Molecular Targets for Cancer Therapy and Prevention
Chest, 2004Despite major improvements in patient management, the prognosis for patients with lung cancer remains dismal. As our knowledge of the molecular biology of cancers has increased, new targets for therapeutic interventions have been identified. In this article, we discuss some of the more recent developments in this field.
Adi F, Gazdar +7 more
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[Molecular targeted therapies].
Nihon rinsho. Japanese journal of clinical medicine, 2010Current treatment paradigms in cancer patients are shifting from cytotoxic chemotherapies alone to single-agent and combination biological and targeted therapies. Targeted therapies are entering standard treatment paradigms. As patient responses to targeted therapies vary, predictive biomarkers will be an important tool of a patient's diagnostic workup
Hideharu, Kimura, Kazuto, Nishio
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Molecular targeted therapy for hepatocellular carcinoma
Journal of Gastroenterology, 2009A majority of patients with HCC present with advanced disease and are not candidates for liver transplantation, surgical resection, or regional therapy. Systemic cytotoxic chemotherapy agents are minimally effective, can have significant toxicity, and have not been shown to improve patient survival. Hepatocellular carcinomas are inherently chemotherapy-
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Targeted molecular therapy for malignant gliomas
Current Treatment Options in Oncology, 2004Advances in our understanding of the molecular changes and resultant cellular effects in malignant glioma are expanding the opportunities for novel targeted therapies. At present, chemotherapy and radiation followed by chemotherapy with nonselective cytotoxic agents is emerging as a standard treatment option for patients with malignant glioma ...
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Molecular Targets and Therapies for Ampullary Cancer
Journal of the National Comprehensive Cancer NetworkAmpullary carcinomas are rare but increasing in incidence. Ampullary cancers have molecular alterations that guide choice of therapy, particularly in nonresectable cases. These alterations can be more common by subtype (intestinal, pancreaticobiliary, or mixed), and next-generation sequencing is recommended for all patients who cannot undergo surgery ...
Monica Arun, Patel +5 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 2003
This article reviews the concept of molecular-targeted therapy and the current development status of molecular-targeted agents for lung cancer. Epidermal growth factor receptor inhibitors have shown promising antitumor activity against cisplatin-resistant non-small cell lung cancer in phase II trials. Appropriate clinical evaluation of these agents and
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This article reviews the concept of molecular-targeted therapy and the current development status of molecular-targeted agents for lung cancer. Epidermal growth factor receptor inhibitors have shown promising antitumor activity against cisplatin-resistant non-small cell lung cancer in phase II trials. Appropriate clinical evaluation of these agents and
openaire +1 more source