Results 101 to 110 of about 774,640 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Molecular detection of bioluminescent dinoflagellates in surface waters of the Patagonian Shelf during early austral summer 2008 [PDF]

, 2014
We investigated the distribution of bioluminescent dinoflagellates in the Patagonian Shelf region using “universal” PCR primers for the dinoflagellate luciferase gene.
Martha Valiadi (576318), Valiadi, M., Allen, John T., M. Debora Iglesias-Rodriguez (402203), M Debora Iglesias-Rodriguez, William M Balch, Painter Stuart C., Stuart C Painter, Iglesias-Rodriguez M. Debora, Painter, S.C., Allen John T., William M. Balch (576321), Stuart C. Painter (576319), Martha Valiadi, Painter, Stuart C., Iglesias-Rodriguez, M.D., Balch William M., Allen, J.T., Balch, William M., Valiadi Martha, Valiadi, Martha, Iglesias-Rodriguez, M. Debora, John T Allen, Balch, W.M., John T. Allen (576320)   +24 more
core   +1 more source

Molecular Weight Distribution of Whole Starch in Rice Endosperm by Gel-permeation Chromatography. [PDF]

J Appl Glycosci (1999), 2023
Suzuki N, Hanashiro I, Fujita N.
europepmc   +1 more source

Comparison of intrinsic characteristics and properties of natural rubber from different origins

Hecheng xiangjiao gongye
Molecular weight and its distribution, gel content, nitrogen and phosphorus content, wet strength, Mooney viscosity, mechanical properties and aging resistance of three kinds of domestic raw natural rubber were compared with those of imported ribbed ...
ZHAO Xin, ZHANG Hao, SUN Quan, JING Yu-long, JIANG Mei-juan, YANG Jing-ting, DU Ming-xin
doaj   +1 more source

Correlação entre o Índice de Fluxo à Fusão e a Função da Distribuição de Cisão de Cadeia durante a degradação termo-mecânica do polipropileno Correlation between Melt Flow Index and Chain Scission Distribution Function during the thermo-mechanical degradation of polypropylene

Polímeros, 2006
Mudanças no Índice de Fluxo à Fusão (MFI) foram correlacionadas com o deslocamento da curva de distribuição de massa molar (MWD) geradas pela degradação termo-mecânica do polipropileno (PP) sujeito a múltiplas extrusões.
Carlos A. Cáceres C., Sebastião V. Canevarolo   +1 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

DISSIPATIVE PARTICLE DYNAMICS SIMULATION STUDY ON CONTROLLING MOLECULAR WEIGHT DISTRIBUTION IN EMULSION POLYMERIZATION

, 2011
The controlling factors on molecular weight distribution in emulsion polymerization are investigated using dissipative particle dynamics simulations. The propagation and bi-radical termination kinetic steps are taken into account in the simulations by ...
JING-MING ZHANG, HONG LIU, CHIA-CHUNG SUN, HUI LI   +3 more
core   +1 more source

Influence of Hydrothermal Treatment of Brewer's Spent Grain on the Concentration and Molecular Weight Distribution of 1,3-1,4-β-D-Glucan and Arabinoxylan. [PDF]

Foods, 2023
Steiner J, Kupetz M, Becker T.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source