Results 91 to 100 of about 3,841,010 (347)

Single-Molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

open access: yesNature Biotechnology, 2010
The ability to detect single protein molecules in blood could accelerate the discovery and use of more sensitive diagnostic biomarkers. To detect low-abundance proteins in blood, we captured them on microscopic beads decorated with specific antibodies ...
David M. Rissin   +14 more
semanticscholar   +1 more source

Effect of Molecules’ Physicochemical Properties on Whey Protein/Alginate Hydrogel Rheology, Microstructure and Release Profile

open access: yesPharmaceutics
The encapsulation of molecules with different physicochemical properties (theophylline, blue dextran, salicylic acid and insulin) in whey protein (WP) and alginate (ALG) microparticles (MP) for oral administration was studied.
A. Delanne-Cuménal   +5 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Optical tweezers in single-molecule biophysics

open access: yesNature Reviews Methods Primers, 2021
C. Bustamante   +3 more
semanticscholar   +1 more source

As4Se4 crystal versus As4Se4 molecule: A plane wave DFT study of the geometric and electronic structure

open access: yesPhysics of Complex Systems
Сhalcogenide crystals reveal a wide range of changes in chemical and physical properties under band gap light illumination. A majority of these properties are determined by the electronic structure.
Антон Андреевич Гавриков   +2 more
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

open access: yesFEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter   +8 more
wiley   +1 more source

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