Results 91 to 100 of about 5,323,640 (377)
Journal of Nucleic Acids, 2022 A high volume of diagnostic tests is needed during the coronavirus disease 2019 (COVID-19) pandemic to obtain representative results. These results can help to design and implement effective policies to prevent the spread of severe acute respiratory ...
Almando Geraldi +2 more
doaj +1 more source
3CLpro inhibitors: DEL-based molecular generation
Frontiers in Pharmacology, 2022 Molecular generation (MG) via machine learning (ML) has speeded drug structural optimization, especially for targets with a large amount of reported bioactivity data.
Feng Xiong +18 more
doaj +1 more source
Reaction kinetics of ultracold molecule-molecule collisions [PDF]
Nature Communications, 2018 AbstractStudying chemical reactions on a state-to-state level tests and improves our fundamental understanding of chemical processes. For such investigations it is convenient to make use of ultracold atomic and molecular reactants as they can be prepared in well defined internal and external quantum states.
Daniel K. Hoffmann +4 more
openaire +8 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Topological states of the diatomic linear chain: effect of impedance matching to the fixed ends
New Journal of Physics, 2020 The diatomic linear chain with nearest-neighbor spring constants C _1 and C _2 has topologically different bulk states for C _1 ≷ C _2 . A finite chain of N unit cells and fixed ends (the first and last spring is C _1 ) exhibits two topological end ...
Marius Grundmann
doaj +1 more source
Nature Physics, 2019 The demonstration of high-resolution spectroscopy of Sr2 molecules trapped in an optical lattice at the ‘magic’ wavelength opens the way to precision control of molecular excitations.
openaire +3 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
, 2011 We study the possibility to use interaction between a polar molecule in the ground electronic and vibrational state and a Rydberg atom to construct two-qubit gates between molecular qubits and to coherently control molecular states.
Amano +30 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Single-molecule pulling: phenomenology and interpretation
, 2013 Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that
Allinger +65 more
core +1 more source