Results 101 to 110 of about 3,532,802 (344)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Pathways and molecules for overcoming immunotolerance in metastatic gastrointestinal tumors

Frontiers in Immunology
Worldwide, gastrointestinal (GI) cancer is recognized as one of the leading malignancies diagnosed in both genders, with mortality largely attributed to metastatic dissemination.
Qixin Gan, Yue Li, Yuejun Li, Haifen Liu, Daochuan Chen, Lanxiang Liu, Churan Peng   +6 more
doaj   +1 more source

Kondo effect in oscillating molecules

, 2009
We consider electronic transport through break-junctions bridged by a single molecule in the Kondo regime. We describe the system by a two-channel Anderson model. We take the tunneling matrix elements to depend on the position of the molecule.
Al-Hassanieh, Balseiro, Bulla, Bulla, Cornaglia, Goldhaber-Gordon, Gunnarsson, Hewson, Jeon, Johansson, Liang, Lucignano, Madhavan, Mravlje, Mravlje, Mravlje, Mravlje, Novotný, Park, Pasupathy, Rejec, Rejec, Schönhammer, Twamley, Wilson, Yu, Yu, Zhao   +27 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Effect of ECAP and volume ultrasonic treatment on the corrosion resistance of magnesium [PDF]

BIO Web of Conferences
Magnesium and its alloys are promising materials for manufacturing bioresorbable implants. Various combinations of thermo-mechanical processing are used to improve the mechanical properties and corrosion resistance of magnesium alloys, forming the ...
Aksenov Denis, Nazarov Airat, Shishkunova Maria, Asfandiyarov Rashid, Sementeeva Yulia   +4 more
doaj   +1 more source

Current Profiles of Molecular Nanowires; DFT Green Function Representation

, 2004
The Liouville-space Green function formalism is used to compute the current density profile across a single molecule attached to electrodes. Time ordering is maintained in real, physical, time, avoiding the use of artificial time loops and backward ...
A. Bachtold, A. Nitzan, A. Nitzan, A.A. Stuchebrukhov, C. Joachim, C.P. Collier, D.S. Kosov, D.S. Kosov, H.B. Weber, I. Lee, J. Reichert, J. Schwinger, J.R. Heath, L.V. Keldysh, M. Di Ventra, M.A. Reed, M.S. Gudiksen, N.D. Lang, N.D. Lang, N.D. Lang, O. Berman, O. Berman, Oleg Berman, S. Mukamel, S. Tretiak, Shaul Mukamel, V. Chernyak, V. Mujica, V. Mujica, X.D. Cui, Y. Xue, Y. Xue   +31 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

BMC Biology, 2018
Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll, Brieuc Chauvin, James W. P. Brown, Ava Meagher, Joanne Coyle, Jurgen Schill, Akshay Bhumkhar, Dominic J. B. Hunter, Thomas Ve, Bostjan Kobe, Emma Sierecki, Yann Gambin   +11 more
doaj   +1 more source