Results 131 to 140 of about 3,841,010 (347)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Rotational Energy Transfer in Diatomic Molecules [PDF]

, 1954
R. Brout
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

XI. The law of attraction amongst the molecules of a gas [PDF]

, 1886
William Sutherland
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Nature Network Boston, 2015
Rebecca C. Coll, A. Robertson, J. Chae, Sarah C. Higgins, Raúl Muñoz-Planillo, Marco C. Inserra, I. Vetter, Lara S. Dungan, Brian G. Monks, A. Stutz, Daniel E. Croker, M. Butler, M. Haneklaus, Caroline E. Sutton, G. Núñez, E. Latz, D. Kastner, K. Mills, S. Masters, K. Schroder, M. Cooper, L. O’Neill   +21 more
semanticscholar   +1 more source

RELATION OF MOLECULE SIZE AND STRUCTURE TO ALCOHOL INHIBITION OF GLUCOSE UTILIZATION BY YEAST [PDF]

, 1956
William D. Gray, Carl Sova
openalex   +1 more source

In silico formulation optimization and particle engineering of pharmaceutical products using a generative artificial intelligence structure synthesis method

Nature Communications
Pharmaceutical drug dosage forms are critical for ensuring the effective and safe delivery of active pharmaceutical ingredients to patients. However, traditional formulation development often relies on extensive lab and animal experimentation, which can ...
Timothy Hornick, Chen Mao, Athanas Koynov, Phillip Yawman, Prajwal Thool, Karthik Salish, Morgan Giles, Karthik Nagapudi, Shawn Zhang   +8 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

ON THE REACTIONS OF BOTH THE IONS AND THE MOLECULES OF ACIDS, BASES AND SALTS. THE REACTIONS OF SODIUM ETHYLATE WITH METHYL IODIDE IN ABSOLUTE ETHYL ALCOHOL AT 25°.⁴ [TWENTY-FIRST⁵ COMMUNICATION ON CATALYSIS.] [PDF]

, 1915
Hayden Robertson, S. F. Acree
openalex   +1 more source