Results 131 to 140 of about 5,095,036 (399)
BMC Biology, 2018 Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll +11 more
doaj +1 more source
Nature Biotechnology, 2010 The ability to detect single protein molecules in blood could accelerate the discovery and use of more sensitive diagnostic biomarkers. To detect low-abundance proteins in blood, we captured them on microscopic beads decorated with specific antibodies ...
David M. Rissin +14 more
semanticscholar +1 more source
Carbon nanotube sensor for vibrating molecules
, 2013 The transport properties of a CNT capacitively coupled to a molecule vibrating along one of its librational modes are studied and its transport properties analyzed in the presence of an STM tip.
Cavaliere, F. +4 more
core +1 more source
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
Arrangement of DOBAMBC molecules inside the capsule on change of the molecule's inclination on the border of the capsule investigated by the molecular dynamics method [PDF]
arXiv, 2012 The method of molecular dynamics is used to investigate the distribution of DOBAMBC molecules in a capsule with the fixed border layer. Change of an arrangement of molecules in smectic layers depending on an inclination of molecules on border is considered.
arxiv
Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
Nature Communications, 2020 During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is ...
Hazal B. Kose +4 more
doaj +1 more source
Single-molecule localization microscopy
Nature Reviews Methods Primers, 2021 M. Lelek +9 more
semanticscholar +1 more source
ABC for Climate: Dealing with Expensive Simulators [PDF]
, 2009 A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels ...
Edwards, Neil +3 more
core
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Optical tweezers in single-molecule biophysics
Nature Reviews Methods Primers, 2021 C. Bustamante +3 more
semanticscholar +1 more source