Results 131 to 140 of about 3,473,423 (297)

Dynamic terahertz spectroscopy of gas molecules mixed with unwanted aerosol under atmospheric pressure using fibre-based asynchronous-optical-sampling terahertz time-domain spectroscopy [PDF]

, 2016
Yi-Da Hsieh, Shota Nakamura, D.G. Abdelsalam, Takeo Minamikawa, Yasuhiro Mizutani, Hirotsugu Yamamoto, Tetsuo Iwata, Francis Hindle, Takeshi Yasui   +8 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

In silico formulation optimization and particle engineering of pharmaceutical products using a generative artificial intelligence structure synthesis method

Nature Communications
Pharmaceutical drug dosage forms are critical for ensuring the effective and safe delivery of active pharmaceutical ingredients to patients. However, traditional formulation development often relies on extensive lab and animal experimentation, which can ...
Timothy Hornick, Chen Mao, Athanas Koynov, Phillip Yawman, Prajwal Thool, Karthik Salish, Morgan Giles, Karthik Nagapudi, Shawn Zhang   +8 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Interaction of innovative small molecule drugs used for cancer therapy with drug transporters [PDF]

, 2011
Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Quantifying antibody binding: techniques and therapeutic implications

mAbs
The binding kinetics of an antibody for its target antigen represent key determinants of its biological function and success as a novel biotherapeutic.
James Lodge, Lewis Kajtar, Rachel Duxbury, David Hall, Glenn A. Burley, Joanna Cordy, James W.T. Yates, Zahra Rattray   +7 more
doaj   +1 more source

Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain

, 2015
Chunyan Ren, Keita Morohashi, A.N. Plotnikov, Jean Jakoncic, Steven M. Smith, Jiaojie Li, Lei Zeng, Yoel Rodrı́guez, V. Stojanoff, Martin J. Walsh, Ming‐Ming Zhou   +10 more
openalex   +2 more sources

Computational Search for Potential COVID-19 Drugs from FDA-Approved Drugs and Small Molecules of Natural Origin Identifies Several Anti-Virals and Plant Products [PDF]

, 2020
Abhishek Sharma, Vikas Tiwari, Ramanathan Sowdhamini   +2 more
openalex   +1 more source

Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis [PDF]

, 2021
Anna‐Lena Unterweger, Morten Ø. Jensen, Fabrizio Giordanetto, Vishwanath Jogini, Alena Rüschher, Marietta Seuß, Paula Winkelmann, Leandra Koletzko, David E. Shaw, Matthias Siebeck, Roswitha Gropp, Florian Beigel, Attila Aszódi   +12 more
openalex   +1 more source