Results 51 to 60 of about 105,165 (285)

Bidirectional Molecule Generation with Recurrent Neural Networks [PDF]

Journal of Chemical Information and Modeling, 2020
ISSN:1549 ...
Francesca Grisoni, Michael Moret, Robin Lingwood, Gisbert Schneider   +3 more
openaire   +2 more sources

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Triplet-Energy Quenching Functions of Antioxidant Molecules

Antioxidants, 2022
UV-like DNA damage is created in the dark by chemiexcitation, in which UV-activated enzymes generate reactive oxygen and nitrogen species that create a dioxetane on melanin.
Carlos Angelé-Martínez, Leticia Christina Pires Goncalves, Sanjay Premi, Felipe A. Augusto, Meg A. Palmatier, Saroj K. Amar, Douglas E. Brash   +6 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Quantum-assisted fragment-based automated structure generator (QFASG) for small molecule design: an in vitro study

Frontiers in Chemistry
Introduction: The significance of automated drug design using virtual generative models has steadily grown in recent years. While deep learning-driven solutions have received growing attention, only a few modern AI-assisted generative chemistry platforms
Sergei Evteev, Yan Ivanenkov, Ivan Semenov, Maxim Malkov, Olga Mazaleva, Artem Bodunov, Dmitry Bezrukov, Denis Sidorenko, Victor Terentiev, Alex Malyshev, Bogdan Zagribelnyy, Anastasia Korzhenevskaya, Alex Aliper, Alex Zhavoronkov   +13 more
doaj   +1 more source

The use of oscillatory signals in the study of genetic networks

, 2005
The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network.
Becskei, Bertero, Gardner, Hasty, Itoh, Kennell, Lee, O. Lipan, Panda, Reppert, Rosenfeld, Sheng, Shimizu-Sato, Storch, van der Horst, Vance, W. H. Wong   +16 more
core   +1 more source

Necessary symmetry conditions for the rotation of light [PDF]

, 2013
Two conditions on symmetries are identified as necessary for a linear scattering system to be able to rotate the linear polarisation of light: Lack of at least one mirror plane of symmetry and electromagnetic duality symmetry.
Fernandez-Corbaton, Ivan, Molina-Terriza, Gabriel, Tischler, Nora, Vidal, Xavier   +3 more
core   +2 more sources

Harmonic generation in free molecules [PDF]

Journal of Physics B: Atomic and Molecular Physics, 1980
A molecular theory of harmonic generation in free molecules is developed using the principles of quantum electrodynamics. A Cartesian tensor formalism is employed and emphasis is placed on the rotational average which is required to account for the random molecular orientations in the pump beam.
openaire   +3 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

The Possibility of Destruction of Cellular NADPH in the Presence of Free Fe(II) Ion, Arsine, and Other Hazardous Species [PDF]

Research in Molecular Medicine, 2022
Background: As the nicotinamide adenine dinucleotide phosphate (NADPH) is the key natural electron generator of the alive cells, investigation of the possibility of inactivation or even destruction of it by hazardous chemical molecules or ions seems to ...
Seyyed Amir Siadati, Mohammad Ali Ebrahimzadeh, Esmaeil Babazadeh   +2 more
doaj