Results 31 to 40 of about 67,913 (286)

Infecções de tecidos moles

Medicina, 2003
Nesta revisão são abordados a etiologia e os principais aspectos clínicos, dermatológicos e terapêuticos das infecções de tecidos moles e das síndromes infecciosas mediadas por toxinas.
Cacilda Silva Souza
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adiabatic Flame Temperature for Combustion of Methane II

Undergraduate Journal of Mathematical Modeling: One + Two, 2013
We calculate the adiabatic flame temperature of a mixture of methane and oxygen in the presence of a diluent gas then determine the mole fractions of methane without respect to nitrogen and solve for the moles of oxygen present.
Rebeca Pupo
doaj   +1 more source

Hunter & Mole

, 2013
We consider a variation of a cops and robbers game in which the cop---here referred to as "hunter"---is not constrained by the graph but must play in the dark against a "mole." We characterize the graphs---which we will call "hunter-win"---on which the hunter can guarantee capture of the mole in bounded time.
Komarov, Natasha, Winkler, Peter
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

General method for the synthesis of enaminones via photocatalysis

Beilstein Journal of Organic Chemistry
Enaminones are key intermediates in the synthesis of several derivatives with important applications in medicinal chemistry. Furthermore, many marketed drugs feature the enaminone structural moiety.
Paula Pérez-Ramos, Raquel G. Soengas, Humberto Rodríguez-Solla   +2 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture. [PDF]

PLoS ONE, 2015
The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g. cell number and media volume.
Claire M Doskey, Thomas J van 't Erve, Brett A Wagner, Garry R Buettner   +3 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Challenging the Bredt’s rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives

Nature Communications
Vinyl carbocations are long known in chemistry but remain less explored than common sp²-hybridized carbocations, and their synthetic applications are limited.
Olaya García-Pedrero, Pilar Pardo, Nerea Alberro, Fernando P. Cossío, Félix Rodríguez   +4 more
doaj   +1 more source