Results 41 to 50 of about 51,668 (264)

Challenging the Bredt’s rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives

Nature Communications
Vinyl carbocations are long known in chemistry but remain less explored than common sp²-hybridized carbocations, and their synthetic applications are limited.
Olaya García-Pedrero, Pilar Pardo, Nerea Alberro, Fernando P. Cossío, Félix Rodríguez   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

De la psychologie du Kitsch en Côte d’Ivoire : pour une approche sociodynamique de la Culture ivoirienne [PDF]

Ziglôbitha, 2022
Résumé : Le titre de l’article est inspiré des travaux d’Abraham Moles. Il est célèbre pour avoir écrit La Psychologie du Kitsch. Dans son ouvrage, il présente le Kitsch comme le mot par lequel la société moderne occidentale se conçoit et se qualifie. En
Axel Richard EBA
doaj  

Worm grunting, fiddling, and charming--humans unknowingly mimic a predator to harvest bait. [PDF]

PLoS ONE, 2008
BackgroundFor generations many families in and around Florida's Apalachicola National Forest have supported themselves by collecting the large endemic earthworms (Diplocardia mississippiensis). This is accomplished by vibrating a wooden stake driven into
Kenneth C Catania
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Analysis of the Efficacy of 5-Fluorouracil in the Treatment of Invasive Moles

Clinical and Experimental Obstetrics & Gynecology
Background: To evaluate the chemotherapy toxicity of 5-fluorouracil (5-FU) in the treatment of invasive moles. Methods: We conducted a retrospective study of therapeutic satisfaction, recurrence, and toxicity in 17 patients treated with 5-FU in the ...
Chunhua Liu, Peilin Ouyang, Yin Tao, Mingyu Xie   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The hydatidiform mole [PDF]

Cell Adhesion & Migration, 2016
The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with the former being followed by an ...
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Recent Advancements in the Utilization of s-Block Organometallic Reagents in Organic Synthesis with Sustainable Solvents

Molecules
This mini-review offers a comprehensive overview of the advancements made over the last three years in utilizing highly polar s-block organometallic reagents (specifically, RLi, RNa and RMgX compounds) in organic synthesis run under bench-type reaction ...
María Jesús Rodríguez-Álvarez, Nicolás Ríos-Lombardía, Sergio E. García-Garrido, Carmen Concellón, Vicente del Amo, Vito Capriati, Joaquín García-Álvarez   +6 more
doaj   +1 more source