Results 61 to 70 of about 68,250 (311)

Moles and Mole Control on British Farms, Amenities and Gardens after Strychnine Withdrawal

Animals, 2016
Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated ...
Sandra E. Baker, Stephen A. Ellwood, Paul J. Johnson, David W. Macdonald   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Recent Advancements in the Utilization of s-Block Organometallic Reagents in Organic Synthesis with Sustainable Solvents

Molecules
This mini-review offers a comprehensive overview of the advancements made over the last three years in utilizing highly polar s-block organometallic reagents (specifically, RLi, RNa and RMgX compounds) in organic synthesis run under bench-type reaction ...
María Jesús Rodríguez-Álvarez, Nicolás Ríos-Lombardía, Sergio E. García-Garrido, Carmen Concellón, Vicente del Amo, Vito Capriati, Joaquín García-Álvarez   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Impact of transition to a subterranean lifestyle on morphological disparity and integration in talpid moles (Mammalia, Talpidae)

BMC Evolutionary Biology, 2019
Background Understanding the mechanisms promoting or constraining morphological diversification within clades is a central topic in evolutionary biology.
Gabriele Sansalone, Paolo Colangelo, Anna Loy, Pasquale Raia, Stephen Wroe, Paolo Piras   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Propriedades geotécnicas de compressibilidade de uma argila mole de Itajaí-SC [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Civil, Florianópolis, 2014.No Brasil os depósitos de solos moles estão localizados ao longo de grande parte da região litorânea ...
Baran, Karin Rodrigues
core  

MOLES3: Implementing an ISO standards driven data catalogue

International Journal of Digital Curation, 2015
ISO19156 Observations and Measurements (O&M) provides a standardised framework for organising information about the collection of information about the environment.  Here we describe the implementation of a specialisation of O&M for environmental data,
Graham A Parton, Steven Donegan, Stephen Pascoe, Ag Stephens, Spiros Ventouras, Bryan N Lawrence   +5 more
doaj   +3 more sources

Expression of Epidermal Growth Factor Receptor (Egfr) in Mole Hydatidiforms, Exaggarated Placental Sites and Normal Placentas and Ki 67 in Mole Hydatidiforms and Normal Placentas

Gynecology Obstetrics & Reproductive Medicine, 2006
OBJECTIVE: The aim of this study is to find out differences between expression of EGFR (epidermal growth f actor receptor) and Ki 67 labeling index (LI) in complete, incomplete mole hydatidiforms, exaggareted placental sites and normal placentas.
Gökben Yıldırım Küpesiz, Hadice Elif Peştereli, Gülgün Erdoğan, Mehmet Şimşek, Fatma Şeyda Karaveli   +4 more
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