Results 171 to 180 of about 8,545 (210)
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A Nanopore Based Molnupiravir Sensor
ACS Sensors, 2022Nucleoside analogues are reagents that resemble the structure of natural nucleosides and are widely applied in antiviral and anticancer therapy. Molnupiravir, a recently reported nucleoside analogue drug, has shown its inhibitory effect against SARS-CoV-2.
Wendong Jia, Chengzhen Hu, Yuqin Wang
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Molnupiravir for the treatment of COVID-19
Drugs of Today, 2022Molnupiravir (MK-4482, EIDD-2801) is a promising broad-spectrum experimental antiviral developed by Merck & Co. It is a nucleoside analogue prodrug that undergoes rapid conversion into nucleoside triphosphate (NTP) by intracellular metabolic processes. NTP inhibits viral polymerase by acting as an alternative substrate.
Bela G, Santani +2 more
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Molnupiravir is effective in patients with haematological malignancies
International Journal of Cancer, 2023AbstractPatients with hematologic malignancies are particularly vulnerable to severe infectious complications. SARS‐CoV‐2 infection is associated with a high risk of severe course and death in this patient population. In addition, immune deficits associated with both the blood cancer and the treatment used make vaccination against SARS‐CoV‐2 less ...
Łukasz Bołkun +16 more
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Molnupiravir in COVID-19: A Scoping Review
Current Drug Research Reviews, 2022Background: COVID-19, first detected in Wuhan, China, has evolved into a lifethreatening pandemic spread across six continents, with the global case count being more than 243 million, and mortality over 4.95 million, along with causing significant morbidity.
Shubham Atal, Shilpa Kaore
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Chemists shorten synthesis of molnupiravir
C&EN Global Enterprise, 2021Chemists have developed an environmentally friendly route for making the investigational antiviral compound molnupiravir from commodity chemicals in just three steps with 69% overall yield.
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A tale of two drugs: Molnupiravir and Paxlovid
Mutation Research - Reviews in Mutation ResearchThe orally administered antiviral drug Lagevrio or molnupiravir (MOV) and the combination antiviral drug nirmatrelvir/ritonavir or Paxlovid (PAX) have been shown to reduce the likelihood of hospitalization and death for high-risk patients with COVID-19.
Michael D. Waters, Stafford G. Warren
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Molnupiravir: evidence by press release
Drug and Therapeutics Bulletin, 2021James A Cave, David Phizackerley
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