Results 41 to 50 of about 532,713 (215)
The History of the Molybdenum Cofactor—A Personal View
Molecules, 2022 The transition element molybdenum (Mo) is an essential micronutrient for plants, animals, and microorganisms, where it forms part of the active center of Mo enzymes.
Ralf R. Mendel
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Microelements and Inherited Metabolic Diseases
Acta Medica, 2002 In addition to the main groups of inherited metabolic diseases, including mitochondrial, peroxisomal and lysosomal defects, organic acidurias, porphyrias, defects of amino acids, saccharides and fatty acids metabolism, disorders of transport and ...
Eliška Marklová
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Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans [PDF]
Genes & Development, 2020 The molybdenum cofactor (Moco) is a 520-Da prosthetic group that is synthesized in all domains of life. In animals, four oxidases (among them sulfite oxidase) use Moco as a prosthetic group. Moco is essential in animals; humans with mutations in genes that encode Moco biosynthetic enzymes display lethal neurological and ...
Kurt Warnhoff +3 more
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Dipstick Diagnosis of Neonatal Seizure Disorder
Pediatric Neurology Briefs, 1998 A dipstick test strip (Sulfistix) showing elevated urinary sulfite concentrations (400 mg/l) was used in diagnosis of molybdenum cofactor deficiency (MCD), an inborn errror of metabolism, in a male infant presenting with convulsions and cerebral ...
J Gordon Millichap
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Copper-deficiency in Brassica napus induces copper remobilization, molybdenum accumulation and modification of the expression of chloroplastic proteins. [PDF]
PLoS ONE, 2014 During the last 40 years, crop breeding has strongly increased yields but has had adverse effects on the content of micronutrients, such as Fe, Mg, Zn and Cu, in edible products despite their sufficient supply in most soils.
Vincent Billard +9 more
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The association of molybdenum cofactor deficiency and pyloric stenosis [PDF]
Journal of Perinatology, 2012 Molybdenum cofactor deficiency (MoCD) is a rare autosomal recessive disorder that may present during the neonatal period with intractable seizures. Co-existence of MoCD and pyloric stenosis is previously reported as a coincidence or common etiology. The etiology of the two conditions is unclear; however, reports demonstrate neuronal deficiency in both.
G, Tezel +5 more
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Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
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The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism
Redox Biology, 2021 Molybdenum cofactor deficiency and isolated sulfite oxidase deficiency are two rare genetic disorders that are caused by impairment of the mitochondrial enzyme sulfite oxidase.
Anna-Theresa Mellis +8 more
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FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
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Advanced Science, EarlyView.Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green +15 more
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