Results 91 to 100 of about 120,575 (162)

The functional principle of eukaryotic molybdenum insertases

, 2018
The molybdenum cofactor (Moco) is a redox-active prosthetic group found in the active site of Moco-dependent enzymes, which are vitally important for life.
Zwerschke, D., Kruse, T., Ralf R. Mendel, Dagmar Zwerschke, Wulf Blankenfeldt, Tobias Kruse, Blankenfeldt, W., Mendel, R.R., Thomas W. Hercher, Krausze, J., Joern Krausze, Martin L. Kirk, Hercher, T.W., Kirk, M.L., Krausze, Joern (author), Mendel, Ralf R. (author), Hercher, Thomas W. (author), Zwerschke, Dagmar (author), Kirk, Martin L. (author), Blankenfeldt, Wulf (author), Kruse, Tobias (author)   +20 more
core   +1 more source

Exploration of the Molybdenum Cofactor gene in the fruit fly Drosophila melangoster

, 2017
Molybdenum (Mo) is an essential trace metal found in most foods. Enzymes that require Mo cannot use this metal unless it is chelated with an organic complex called the Mo cofactor.
McQualter, Jazmyne, Ibsen, Camille
core  

Investigation of molybdenum cofactor deficiency due to MOCS2 deficiency in a newborn baby

, 2015
Background: Molybdenum cofactor deficiency (MOCD) is a severe autosomal recessive neonatal metabolic disease that causes seizures and death or severe brain damage.
Allgood, Catherine (R17910), Edwards, Matthew (R16367), Chin, Raymond (R17897), Schwarz, Guenter, Whitehall, John (R15925), Santamaria, Jose A., Roeper, Juliane, Wong, Flora   +7 more
core   +1 more source

Molybdenum’s Role as an Essential Element in Enzymes Catabolizing Redox Reactions: A Review

Biomolecules
Molybdenum (Mo) is an essential element for human life, acting as a cofactor in various enzymes crucial for metabolic homeostasis. This review provides a comprehensive insight into the latest advances in research on molybdenum-containing enzymes and ...
Jakub Piotr Adamus, Anna Ruszczyńska, Aleksandra Wyczałkowska-Tomasik   +2 more
doaj   +1 more source

A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin

Neural Development
Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin (Gphn)-null mice, where glycine receptors are depleted from synaptic ...
Emma J. Brennan, Kelly R. Monk, Jiaxing Li   +2 more
doaj   +1 more source

Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levels

, 2007
Many efforts have been made in recent decades to understand how coenzymes, including vitamins, are synthesised in organisms. In the present review, we describe the most recent findings about the biological roles of five coenzymes: folate (vitamin B9 ...
Warren, Martin J, Smith, Alison G., Warren, Martin J., Smith, Alison G, Mendel, Ralf R, Rébeillé, Fabrice, Ravanel, Stéphane, Marquet, Andrée, Mendel, Ralf R.   +8 more
core   +1 more source

The chaperone FdsC for Rhodobacter capsulatus formate dehydrogenase binds the bis-molybdopterin guanine dinucleotide cofactor

, 2014
Molybdoenzymes are complex enzymes in which the molybdenum cofactor (Moco) is deeply buried in the enzyme. Most molybdoenzymes contain a specific chaperone for the insertion of Moco.
Leimkühler, Silke (Prof. Dr.), Boehmer, Nadine, Hartmann, Tobias   +2 more
core   +1 more source

Rhodobacter capsulatus XdhC is involved in molybdenum cofactor binding and insertion into xanthine dehydrogenase

, 2006
Rhodobacter capsulatus xanthine dehydrogenase (XDH) is a cytoplasmic enzyme with an (alpha beta) 2 heterodimeric structure that is highly identical to homodimeric eukaryotic xanthine oxidoreductases.
Leimkühler, Silke (Prof. Dr.), Jünemann, Nora, Schulte, Marc, Stöcklein, Walter F. M., Neumann-Schaal, Meina   +4 more
core   +1 more source

OsABA3 is Crucial for Plant Survival and Resistance to Multiple Stresses in Rice

Rice
Preharvest sprouting (PHS) is a serious problem in rice production as it leads to reductions in grain yield and quality. However, the underlying mechanism of PHS in rice remains unclear.
Haoling Ni, Wenshi Wu, Yanmin Yan, Yiyuan Fang, Changjian Wang, Jiayi Chen, Shali Chen, Kaini Wang, Chunjue Xu, Xiaoyan Tang, Jianxin Wu   +10 more
doaj   +1 more source

Identification of YdhV as the First Molybdoenzyme Binding a Bis-Mo-MPT Cofactor in Escherichia coli

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Stefan Mebs (1455724), Michael Haumann (1455718), Stefan Reschke (1625572), Peer Schrapers, Christian Teutloff, Holger Dau, Stefan Mebs, Michael Haumann, Holger Dau (1625578), Silke Leimkühler, Benjamin R. Duffus (1876399), Stefan Reschke, Peer Schrapers (1625575), Christian Teutloff (498027), Benjamin R. Duffus, Silke Leimkühler (1327842)   +15 more
core   +1 more source