Results 71 to 80 of about 120,575 (162)

Cysteine Signalling in Plant Pathogen Response

Plant, Cell &Environment, Volume 48, Issue 10, Page 7107-7122, October 2025.
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Jannis Moormann, Björn Heinemann, Cecile Angermann, Anna Koprivova, Ute Armbruster, Stanislav Kopriva, Tatjana M. Hildebrandt   +6 more
wiley   +1 more source

Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization

, 2000
The molybdenum cofactor (Moco). a highly conserved pterin compound coordinating molybdenum (Mo), is required for the enzymatic activities of molybdoenzymes.
Palmer, T., Schwarz, G., Mendel, Ralf R, Schwarz, Gunter, Mendel, R.R., Kuper, Jochen, Palmer, Tracy, Kuper, J.   +7 more
core   +1 more source

Adaptive Tolerance of Listeria monocytogenes to Chemical Oxidants: Comparative Analysis of Transcriptomic Studies

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 5, September 2025.
ABSTRACT Listeria monocytogenes is a foodborne pathogen that poses significant challenges to food safety and public health due to its ability to adapt to harsh environments, particularly those found in food processing facilities. This review explores the global transcriptional responses of L.
Nagendran Rajalingam, Sam Van Haute
wiley   +1 more source

Phosphoinositide‐ and Collybistin‐Dependent Synaptic Clustering of Gephyrin

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Gephyrin is the main scaffolding protein at inhibitory synapses, clustering glycine and GABAA receptors. At specific GABAergic synapses, collybistin recruits gephyrin to the postsynaptic membrane via interaction with phosphoinositides. Here, we show that collybistin not only mediates membrane targeting but also induces gephyrin self‐oligomerization ...
Nele Burdina, Filip Liebsch, Arthur Macha, Joaquín Lucas Ortuño Gil, Pia Frommelt, Irina Rais, Fabian Basler, Simon Pöpsel, Guenter Schwarz   +8 more
wiley   +1 more source

The regulation of Moco biosynthesis and molybdoenzyme gene expression by molybdenum and iron in bacteria

, 2019
International audienceBacterial molybdoenzymes are key enzymes involved in the global sulphur, nitrogen and carbon cycles. These enzymes require the insertion of the molybdenum cofactor (Moco) into their active sites and are able to catalyse a large ...
Leimkuhler, Silke, Leimkühler, Silke (Prof. Dr.), Zupok, Arkadiusz, Méjean, Vincent, Iobbi-Nivol, Chantal   +4 more
core   +1 more source

ModE Regulates Alternative Nitrogenase Expression in the Methanogen Methanosarcina acetivorans

Molecular Microbiology, Volume 124, Issue 2, Page 105-114, August 2025.
During nitrogen fixation, the methanogen Methanosarcina acetivorans produces the alternative vanadium‐nitrogenase and iron‐nitrogenase only when molybdenum is unavailable to support the activity of molybdenum‐nitrogenase. Our work demonstrates that the expression of the alternative nitrogenases in M.
Melissa Chanderban, Daniel J. Lessner
wiley   +1 more source

Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site

, 2018
The molybdenum cofactor (Moco) is a molybdenum-conjugated prosthetic group that is ubiquitously found in plants, animals, and bacteria. Moco is required for the nitrogen-reducing reaction of the Moco sulfurase C-terminal domain (MOSC) family. Despite the
Sung-il Yoon, Jee-Hyeon Kim, Byeol Namgung, Wan Seok Song   +3 more
core   +1 more source

Human aldehyde oxidase (hAOX1): structure determination of the Moco‐free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

FEBS Open Bio, 2019
Human aldehyde oxidase (hAOX1) is a molybdenum enzyme with high toxicological importance, but its physiological role is still unknown. hAOX1 metabolizes different classes of xenobiotics and is one of the main drug‐metabolizing enzymes in the liver, along
Cristiano Mota, Mariam Esmaeeli, Catarina Coelho, Teresa Santos‐Silva, Martin Wolff, Alessandro Foti, Silke Leimkühler, Maria João Romão   +7 more
doaj   +1 more source

The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro. [PDF]

Int J Parasitol
Sulphite oxidase has an essential role in detoxifying environmental and endogenously generated sulphite into sulphate and requires the molybdenum cofactor (Moco) to function.
Brinzer RA, McIntyre JR, Britton C, Laing R.   +3 more
europepmc   +2 more sources

The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis

, 2005
Molybdenum cofactor (Moco)-deficiency is a lethal autosomal recessive disease, for which until now no effective therapy is available. The biochemical hallmark of this disorder is the inactivity of the Moco-dependent sulfite oxidase, which results in ...
Schwarz, Günter, Wagner, Silke, Schwegler, Herbert, Garattini, Enrico, Lee, Heon-Jin, Riess, Olaf, Engel, Wolfgang, Saß, Jörn-Oliver, Bonin, Michael, Sass, Jörn Oliver, Reiss, Jochen   +10 more
core   +1 more source