Results 51 to 60 of about 120,575 (162)

Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli

, 2013
Molybdenum cofactor (Moco) biosynthesis is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum.
Leimkühler, Silke (Prof. Dr.), Iobbi-Nivol, Chantal   +1 more
core   +1 more source

Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis. [PDF]

PLoS ONE, 2013
A companion manuscript revealed that deletion of the Pseudomonas aeruginosa (Pae) PA1006 gene caused pleiotropic defects in metabolism including a loss of all nitrate reductase activities, biofilm maturation, and virulence.
Gregory Tombline, Johanna M Schwingel, John D Lapek, Alan E Friedman, Thomas Darrah, Michael Maguire, Nadine E Van Alst, Melanie J Filiatrault, Barbara H Iglewski   +8 more
doaj   +1 more source

S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish

Frontiers in Pharmacology, 2019
Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of
Jennifer Plate, Wiebke A. Sassen, Ahmed H. Hassan, Franziska Lehne, Reinhard W. Köster, Tobias Kruse   +5 more
doaj   +1 more source

Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency

Frontiers in Genetics, 2021
Molybdenum cofactor deficiency (MoCD) is an autosomal recessive disorder belonging to the large family of inborn errors in metabolism. Patients typically present with encephalopathy and seizures early after birth and develop severe neurodegeneration ...
Anna-Theresa Mellis, Juliane Roeper, Albert L. Misko, Joshua Kohl, Guenter Schwarz, Guenter Schwarz   +5 more
doaj   +1 more source

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli

, 2004
Substitution therapies for orphan genetic diseases, including enzyme replacement methods, are frequently hampered by the limited availability of the required therapeutic substance. We describe the isolation of a pterin intermediate from bacteria that was
Otte, T., Lee, H. J., Grone, H. J., Engel, Wolfgang, Adham, Ibrahim M., Sass, Joern Oliver, Mendel, R. R., Wolf, S., Schwarz, Guenter, Hanzelmann, P., Santamaria-Araujo, Jose Angel, Schwegler, H., Reiss, Jochen, Schwarz, Günter   +13 more
core   +1 more source

Molybdenum Cofactor Insertion in Escherichia coli Dimethyl Sulfoxide Reductase

, 2012
Molybdenum is a metal present in all forms of life. Most commonly, it forms the molybdenum cofactor (Moco) in the active site of molybdoenzymes. In bacteria, dimethyl sulfoxide (DMSO) reductase is a molybdoenzyme that is part of the anaerobic respiratory
Tang, Huipo
core   +1 more source

Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Duffus, Benjamin R., Reschke, Stefan, Teutloff, Christian, Leimkühler, Silke, Schrapers, Peer, Dau, Holger, Mebs, Stefan, Haumann, Michael   +7 more
core   +2 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source