Results 31 to 40 of about 120,575 (162)
Engineering of molybdenum-cofactor-dependent nitrate assimilation in Yarrowia lipolytica
, 2021 Engineering a new metabolic function in a microbial host can be limited by the availability of the relevant cofactor. For instance, in Yarrowia lipolytica, the expression of a functional nitrate reductase is precluded by the absence of molybdenum ...
Borodina, Irina (author) +8 more
core +1 more source
Isolation and characterisation of chlorate resistant mutants of barley [PDF]
, 2012 The object of this study has been to characterise barley mutants which lack the functional nitrate reductase (NR) enzyme system. In the long term it is hoped that such studies will lead to improved nitrate utilisation and ultimately to improved ...
Steven, Barbara
core +1 more source
Chlamydomonas reinhardtii—A Reference Microorganism for Eukaryotic Molybdenum Metabolism
Microorganisms, 2023 Molybdenum (Mo) is vital for the activity of a small but essential group of enzymes called molybdoenzymes. So far, specifically five molybdoenzymes have been discovered in eukaryotes: nitrate reductase, sulfite oxidase, xanthine dehydrogenase, aldehyde ...
Manuel Tejada-Jimenez +2 more
doaj +1 more source
Molybdenum Cofactor Biosynthesis
, 2016 The biosynthesis of the molybdenum cofactor (Moco) is highly conserved among all kingdoms of life. In all molybdoenzymes with the exception of nitrogenase, the molybdenum atom is coordinated to a dithiolene group present in the pterin-based 6-alkyl side ...
Mendel, Ralf-Rainer (Prof. Dr.) +1 more
core +1 more source
Molybdenum cofactor deficiency: Mutations in GPHN, MOCS1, and MOCS2
, 2010 International audienceAll molybdenum-containing enzymes other than the bacterial nitrogenase share an identical molybdenum cofactor (MoCo), which is synthesized via a conserved pathway in all organisms and therefore also is called "universal molybdenum ...
Jochen Reiss +3 more
core +1 more source
Shared function and moonlighting proteins in molybdenum cofactor biosynthesis
, 2017 The biosynthesis of the molybdenum cofactor (Moco) is a highly conserved pathway in bacteria, archaea and eukaryotes. The molybdenum atom in Moco-containing enzymes is coordinated to the dithiolene group of a tricyclic pyranopterin monophosphate cofactor.
Leimkühler, Silke (Prof. Dr.) +1 more
core +1 more source
The peacefulness gene promotes aggression in Drosophila
Molecular Brain, 2019 Natural aggressiveness is commonly observed in all animal species, and is displayed frequently when animals compete for food, territory and mating. Aggression is an innate behaviour, and is influenced by both environmental and genetic factors.
Mahmoudreza Ramin +4 more
doaj +1 more source
, 2022 Over 50 molybdenum enzymes in three distinct families (sulfite oxidase, xanthine oxidase, DMSO reductase) are known, and representative X-ray crystal structures are available for all families.
Enemark, John H., John H. Enemark
core +1 more source
Identification and characterization of the Volvox carteri Moco carrier protein [PDF]
, 2020 The molybdenum cofactor (Moco) is a redox active prosthetic group found in the active site of Moco-dependent enzymes (Mo-enzymes). As Moco and its intermediates are highly sensitive towards oxidative damage, these are believed to be permanently protein ...
Kirk, Martin L. +9 more
core +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source