Results 41 to 50 of about 120,575 (162)

Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency

, 1998
Reiss J, Cohen N, Dorche C, et al. Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency. NATURE GENETICS. 1998;20(1):51-53.All molybdoenzymes other than nitrogenase require molyb-dopterin as a metal-binding cofactor(1).
Dierks, Thomas, Dorche, C, Cohen, N, Mandel, H, Reiss, J, Mendel, RR, Stallmeyer, B, Zabot, MT   +7 more
core   +1 more source

Overexpression of a GmCnx1 gene enhanced activity of nitrate reductase and aldehyde oxidase, and boosted mosaic virus resistance in soybean.

PLoS ONE, 2015
Molybdenum cofactor (Moco) is required for the activities of Moco-dependant enzymes. Cofactor for nitrate reductase and xanthine dehydrogenase (Cnx1) is known to be involved in the biosynthesis of Moco in plants.
Zheng Zhou, Hongli He, Luping Ma, Xiaoqian Yu, Qian Mi, Jingsong Pang, Guixiang Tang, Bao Liu   +7 more
doaj   +1 more source

A milder form of molybdenum cofactor deficiency type A presenting as Leigh's syndrome-like phenotype highlighting the secondary mitochondrial dysfunction: a case report

Frontiers in Neurology, 2023
BackgroundMolybdenum cofactor deficiency (MoCD) (OMIM# 252150) is an autosomal-recessive disorder caused by mutations in four genes involved in the molybdenum cofactor (MOCO) biosynthesis pathway.ObjectivesWe report a milder phenotype in a patient with ...
Montaha Almudhry, Montaha Almudhry, Asuri N. Prasad, Asuri N. Prasad, Asuri N. Prasad, C. Anthony Rupar, C. Anthony Rupar, C. Anthony Rupar, Keng Yeow Tay, Keng Yeow Tay, Suzanne Ratko, Mary E. Jenkins, Mary E. Jenkins, Chitra Prasad, Chitra Prasad   +14 more
doaj   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor

, 2017
The molybdenum cofactor (Moco) is a redox active prosthetic group, essentially required for numerous enzyme-catalyzed two electron transfer reactions. Moco is synthesized by an evolutionarily old and highly conserved multistep pathway.
Krausze, Joern (author), Reichelt, Joachim (author), Probst, Corinna (author), Curth, Ute (author), Saha, Sayantan (author), Schafflick, David (author), Mendel, Ralf R. (author), Kruse, Tobias (author), Heinz, Dirk W. (author)   +8 more
core   +1 more source

Elucidation of the dual role of Mycobacterial MoeZR in molybdenum cofactor biosynthesis and cysteine biosynthesis.

PLoS ONE, 2011
The pathway of molybdenum cofactor biosynthesis has been studied in detail by using proteins from Mycobacterium species, which contain several homologs associated with the first steps of Moco biosynthesis.
Martin Voss, Manfred Nimtz, Silke Leimkühler   +2 more
doaj   +1 more source

Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Plant Biology, EarlyView.
Transcript correlation analysis allowed the identification of several key nodes in the complex regulatory network of plant iron metabolism. Abstract Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide.
I. Murgia, P. Morandini
wiley   +1 more source

Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis

, 2016
The molybdenum cofactor (Moco) is essential for the catalytic activity of all molybdenum-containing enzymes with the exception of nitrogenase. Moco biosynthesis follows an evolutionarily highly conserved pathway and genetic deficiencies in the ...
Schindelin, Hermann, Kasaragod, Vikram Babu   +1 more
core   +1 more source

The structure of the Moco carrier protein from <em>Rippkaea orientalis</em> [PDF]

, 2020
The molybdenum cofactor (Moco) is the prosthetic group of all molybdenum-dependent enzymes except for nitrogenase. The multistep biosynthesis pathway of Moco and its function in molybdenum-dependent enzymes are already well understood.
Krausze, Joern (author), Hercher, Thomas W. (author), Archna, Archna (author), Kruse, Tobias (author)   +3 more
core   +1 more source

Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes

BMC Genomics, 2018
Background Molybdenum (Mo) is an essential micronutrient for almost all biological systems, which holds key positions in several enzymes involved in carbon, nitrogen and sulfur metabolism.
Ting Peng, Yinzhen Xu, Yan Zhang
doaj   +1 more source