Results 11 to 20 of about 120,575 (162)
Inorganics, 2020 Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containing ...
Ralf R. Mendel +4 more
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Tungstoenzymes: Occurrence, Catalytic Diversity and Cofactor Synthesis
Inorganics, 2020 Tungsten is the heaviest element used in biological systems. It occurs in the active sites of several bacterial or archaeal enzymes and is ligated to an organic cofactor (metallopterin or metal binding pterin; MPT) which is referred to as tungsten ...
Carola S. Seelmann +3 more
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The First Step of Neurospora crassa Molybdenum Cofactor Biosynthesis: Regulatory Aspects under N-Derepressing and Nitrate-Inducing Conditions [PDF]
Microorganisms, 2020 Molybdenum cofactor (Moco) is the active site prosthetic group found in all Moco dependent enzymes, except for nitrogenase. Mo-enzymes are crucial for viability throughout all kingdoms of life as they catalyze a diverse set of two electron transfer ...
Simon Wajmann +5 more
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Molybdenum Cofactor Deficiency in Humans
Molecules, 2022 Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to hypoxic–ischemic lesions.
Lena Johannes +2 more
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Convergent evolution links molybdenum insertase domains with organism-specific sequences [PDF]
Communications BiologyIn all domains of life, the biosynthesis of the pterin-based Molybdenum cofactor (Moco) is crucial. Molybdenum (Mo) becomes biologically active by integrating into a unique pyranopterin scaffold, forming Moco. The final two steps of Moco biosynthesis are
Miriam Rabenow +5 more
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Epigenetic Regulation of the BDNF Gene by Molybdenum in 9 to 11-Year-Old Children: A Targeted Gene DNA Methylation Study. [PDF]
Mol Nutr Food ResThis study examined associations between molybdenum (Mo) status and DNA methylation of the brain‐derived neurotrophic factor (BDNF) gene in children aged 9–11 years. Dietary Mo intake was estimated from food records, and creatinine‐adjusted urinary Mo levels were quantified.
Voss MA +7 more
europepmc +2 more sources
Novel roles of sulfur metabolism in stress-controlled stomata aperture regulation. [PDF]
New PhytolSummary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sun SK, Hell R, Wirtz M.
europepmc +2 more sources
One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives [PDF]
ChembiochemThe terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Leimkühler S, Duffus B, Schulzke C.
europepmc +2 more sources
Molybdenum – a scoping review for Nordic Nutrition Recommendations 2023
Food & Nutrition Research, 2023 Molybdenum is an essential element in the form of the molybdenum cofactor (Moco). In humans, Moco is required for four enzymes: xanthine oxidase (XO), aldehyde oxidase, sulfite oxidase (SO), and mitochondrial amidoxime-reducing component (mARC).
Agneta Oskarsson, Maria Kippler
doaj +1 more source
Engineering-Modulated Molybdenum Enzymes Strategy for Tumor-Specific Metabolic-Immunotherapy. [PDF]
Adv Sci (Weinh)Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Pan X +14 more
europepmc +2 more sources