Results 111 to 120 of about 95,145 (229)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Field‐Assisted Substrate Ionization as a Plausible Initiating Step in Enzyme Catalysis

International Journal of Quantum Chemistry, Volume 126, Issue 19, October 5, 2026.
Strong, spatially heterogeneous electrostatic fields within enzyme active sites may facilitate field‐assisted electron tunneling from bound substrates, transiently generating radical‐cation character and opening alternative pathways for catalytic activation.
Marianne Kerleaux, Florian Regnier, Jean‐Nicolas Vigneau, Chérif F. Matta   +3 more
wiley   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Multifunctional Rhizobacterial Consortia Enhance Growth and Yield of Common Bean Across Field Conditions

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Consortia of plant growth‐promoting rhizobacteria (PGPR) enhance the growth and development of common bean plants, improving root system development, nutrient use efficiency and grain yield. These bioinputs reduce dependence on mineral fertilizers and support eco‐efficient agriculture, offering a sustainable alternative in diverse soil and climate ...
Ana Paula Santos Oliveira, Cássia Cristina Rezende Mirza, Cleiton Mateus Sousa, Enderson Petrônio de Brito Ferreira   +3 more
wiley   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

Synthesis and characterization of molybdenum and vanadium framework materials

Molybdenum and vanadium inorganic framework materials, with structures based on phosphate and arsenate tetrahedra have been synthesised by hydrothermal techniques and characterised by single crystal X-ray diffraction; additional techniques including ...
Kotsapa, Eleni
core   +1 more source

A factorial multi‐layer analysis reveals non‐additive sulfur–iron interactions shaping metabolic and transcriptional responses in durum wheat

New Phytologist, Volume 252, Issue 1, Page 192-208, October 2026.
Working model of S‐dependent Fe stress integration in durum wheat. S availability acts as the main factor defining the metabolic and transcriptional state of the plant, whereas Fe mainly affects the intensity of these responses. This is particularly evident for OAS, methionine, citrate and asparagine, which accumulated most strongly under combined S ...
Eleonora Coppa, Mutsumi Watanabe, Moez Maghrebi, Giulia Quagliata, Alessandro Bruschini, Rainer Hoefgen, Youry Pii, Stefano Cesco, Gianpiero Vigani, Stefania Astolfi   +9 more
wiley   +1 more source