Results 121 to 130 of about 95,145 (229)

New components in genetic regulation of age‐dependent compound leaf architecture in pea

New Phytologist, Volume 252, Issue 2, Page 909-925, October 2026.
Compound leaf development in pea (Pisum sativum). Summary Pea (Pisum sativum L.) is a classic model for compound leaf development. Pea leaves typically consist of a proximal series of paired lateral leaflets substituted distally by filiform tendrils, and the number of lateral organ pairs increases with ontogeny.
Jacqueline K. Vander Schoor, Chantelle J. Beagley, Warwick Gill, Grégoire Aubert, Judith Burstin, Robert J. E. Wiltshire, Valérie Hecht, James L. Weller   +7 more
wiley   +1 more source

Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester, Skye Lau, Miguel Benitez‐Angeles, Christopher J. Garland, Vincenzo Barrese, Anthony P. Albert, Iain A. Greenwood   +6 more
wiley   +1 more source

Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Ro 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Carlos Cruz‐Cortés, Jaroslava Šeflová, Guadalupe Guerrero‐Serna, Eric N. Jimenez‐Vazquez, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +5 more
wiley   +1 more source

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss, Curtis E. Moore, Shiyu Zhang   +2 more
wiley   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, Volume 20, Issue 9, Page 2356-2381, September 2026.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Hierarchical Assembly as a Design Principle: Structure–Property Relationships Linking Biological Architectures to Functional Aggregate Materials

Aggregate, Volume 7, Issue 9, September 2026.
Biological function arises from aggregates rather than from molecules. Comparing biomimetic systems on a common basis reveals three transferable design rules governing hierarchical assembly, interfacial gradients, and stimulus‐coupled anisotropy, and identifies self‐healing and single‐step multiscale integration as properties that do not transfer to ...
Nafeesa Sarfraz, Sadaf Bibi, Muhammad Ibrar Ahmed, Jawad Hussain, Shahid Iqbal, Imran Mahmood Khan, Ajayan Vinu, Ibrahim Khan   +7 more
wiley   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

Molybdenum Cofactor Biosynthesis [PDF]

Journal of Biological Chemistry, 1997
Günter Schwarz, David H. Boxer, Ralf R. Mendel   +2 more
openaire   +1 more source