Results 11 to 20 of about 945 (112)
Molybdopterin Dinucleotide Biosynthesis in Escherichia coli [PDF]
Journal of Biological Chemistry, 2011 The molybdenum cofactor is modified by the addition of GMP or CMP to the C4' phosphate of molybdopterin forming the molybdopterin guanine dinucleotide or molybdopterin cytosine dinucleotide cofactor, respectively.
Leimkühler, Silke (Prof. Dr.) +7 more
core +2 more sources
FEBS Letters, 1991 Formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum was purified to apparent homogeneity and found to contain per mol (apparent molecular mass 110 kDa) 0.6 mol molybdenum, 4 mol non-heme iron, 4 mol acid-labile sulfur, in addition,
Thauer, R. +5 more
core +4 more sources
Reconstitution of Molybdoenzymes with Bis-Molybdopterin Guanine Dinucleotide Cofactors [PDF]
, 2018 International audienceMolybdoenzymes are ubiquitous, and play important roles in all kingdoms of life. The enzymes' cofactors comprise the metal molybdenum, a special organic ligand system called molybdopterin (MPT), additional small ligands like water ...
Leimkuhler, Silke +5 more
core +4 more sources
Coupling Pyrazine to Dithiocarbonates for Molybdopterin Model Ligands—Indispensable Tin [PDF]
Inorganics, 2023 Several synthetic cross-coupling procedures were (re-)evaluated for the tethering of pyrazine to dithiocarbonates. The resultant species constitute pro-ligands and can be converted by removal of the C=O moiety into ene-dithiolate ligand systems that ...
Siva Sankar Murthy Bandaru +7 more
core +3 more sources
In vitro system for molybdopterin biosynthesis [PDF]
Journal of Bacteriology, 1987 A high-Mr fraction present in chl+ and chlA1 strains of Escherichia coli synthesizes molybdopterin (MPT) from the low-Mr fraction of several MPT-deficient mutants. Using this in vitro complementation as an assay, we have partially characterized the high-Mr fraction as a protein, termed MPT converting factor, of Mr 45,000, distinguishable from the Mo ...
M E, Johnson, K V, Rajagopalan
openaire +2 more sources
Mechanistic and Mutational Studies of Escherichia coli Molybdopterin Synthase Clarify the Final Step of Molybdopterin Biosynthesis [PDF]
Journal of Biological Chemistry, 2003 Biosynthesis of the molybdenum cofactor, a chelate of molybdenum or tungsten with a novel pterin, occurs in virtually all organisms including humans. In the cofactor, the metal is complexed to the unique cis-dithiolene moiety located on the pyran ring of molybdopterin.
Margot M, Wuebbens, K V, Rajagopalan
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Functional Analysis of Molybdopterin Biosynthesis in Mycobacteria Identifies a Fused Molybdopterin Synthase in Mycobacterium tuberculosis [PDF]
Journal of Bacteriology, 2011 ABSTRACT Most mycobacterial species possess a full complement of genes for the biosynthesis of molybdenum cofactor (MoCo). However, a distinguishing feature of members of the Mycobacterium tuberculosis complex is their possession of multiple homologs associated with the first two steps of the MoCo ...
Monique J, Williams +2 more
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, 2022 The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the
Iobbi-Nivol, Chantal (Dr.) +2 more
core +2 more sources
, 1999 We describe the primary structure of eukaryotic molybdopterin synthase small and large subunits and compare the sequences of the lower eukaryote, Aspergillus nidulans, and a higher eukaryote, Homo sapiens. Mutants in the A.
Heck, IS +4 more
core +3 more sources
Structural characterization of a molybdopterin precursor
Journal of Biological Chemistry, 1993 Purification and structural characterization of a novel pterin that is the immediate biosynthetic precursor for molybdopterin formation in Escherichia coli has been accomplished. The precursor is purified from acid extracts of cells of the Escherichia coli molybdopterin-deficient mutant chlN by reverse phase and ion exchange high performance liquid ...
M M, Wuebbens, K V, Rajagopalan
openaire +2 more sources