Results 51 to 60 of about 37,979 (336)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
General predictions for the neutron star crustal moment of inertia [PDF]
Physical Review C, 2018 The neutron star crustal EoS and transition point properties are computed within a unified meta-modeling approach. A Bayesian approach is employed including two types of filters: bulk nuclear properties are controlled from low density effective field ...
T. Carreau, F. Gulminelli, J. Margueron
semanticscholar +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
ESTIMATION OF INERTIA MOMENT OF CAR ENGINE MOVING PARTS [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2018 Problem. To calculate the car dynamics, especially in urban conditions with frequent transitions to lower gears, the values of the inertia moment (MI) or the equivalent mass (EM) of the engine moving parts, brought to the crankshaft, are required ...
Rabinovich E., Zytsev Yu., Kalekin V.
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source
Satellite Inertia Parameters Estimation Based on Extended Kalman Filter
Journal of Aerospace Technology and Management, 2019 The moment of inertia parameters plays a critical role in assuring the spacecraft mission throughout its lifetime. However, determination of the moment of inertia is a key challenge in operating satellites.
Abdellatif Bellar +1 more
doaj +3 more sources
FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
Observer Design for a Variable Moment of Inertia System
Energies, 2021 Variable moment of inertia systems are common, and a popular laboratory system of this type is the “ball-and-beam”. Such systems are, however, nonlinear and often unstable. Efficient control requires full state information (or at least partial velocities)
Jerzy Baranowski
doaj +1 more source