Results 41 to 50 of about 251,836 (304)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The operator approach to the truncated multidimensional moment problem
Concrete Operators, 2019 We study the truncated multidimensional moment problem with a general type of truncations. The operator approach to the moment problem is presented. The case where the associated operators form a commuting self-adjoint tuple is characterized in terms of ...
Zagorodnyuk Sergey M.
doaj +1 more source
Plate-Like Flexible Spacecraft Modeling and Distribution of Control Moment Gyroscopes
Space: Science & Technology, 2023 This study investigates the optimization configuration problem of control moment gyroscopes for flexible vibration suppression of large space structures.
Jingyu Guo +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Strong CP problem, electric dipole moment, and fate of the axion
SciPost Physics Proceedings, 2022 Three hard problems! In this talk I investigate the long-distance properties of quantum chromodynamics in the presence of a topological theta term. This is done on the lattice, using the gradient flow to isolate the long-distance modes in the functional ...
Gerrit Schierholz
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
NCoder—a quantum field theory approach to encoding data
Machine Learning: Science and TechnologyIn this paper we present a novel approach to interpretable AI inspired by quantum field theory which we call the NCoder . The NCoder is a modified autoencoder neural network whose latent layer is prescribed to be a subset of n -point correlation ...
D S Berman, M S Klinger, A G Stapleton
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Hausdorff moment problem via fractional moments [PDF]
Applied Mathematics and Computation, 2003 We outline an efficient method for the reconstruction of a probability density function from the knowledge of its infinite sequence of ordinary moments. The approximate density is obtained resorting to maximum entropy technique, under the constraint of some fractional moments. The latter ones are obtained explicitly in terms of the infinite sequence of
Novi Inverardi, Pier Luigi +3 more
openaire +5 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source