Results 61 to 70 of about 210,059 (263)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Solution of the Stieltjes truncated matrix moment problem [PDF]

Opuscula Mathematica, 2005
The truncated Stieltjes matrix moment problem consisting in the description of all matrix distributions \(\boldsymbol{\sigma}(t)\) on \([0,\infty)\) with given first \(2n+1\) power moments \((\mathbf{C}_j)_{n=0}^j\) is solved using known results on the ...
Vadim M. Adamyan, Igor M. Tkachenko
doaj  

Relation between Exponential Moment Problem and Classical Moment Problem

Proceedings of the Bulgarian Academy of Sciences
The main result of the paper is an interesting relation between the solution of the truncated exponential moment problem and truncated classical moment problem, considered on the half-line or on a compact interval.
Kounchev, O., Render, H., Tsachev, Ts.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Maximum Entropy and Moment Problems

Real Analysis Exchange, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Coherent State Quantization and Moment Problem

Acta Polytechnica, 2010
Berezin-Klauder-Toeplitz (“anti-Wick”) or “coherent state” quantization of the complex plane, viewed as the phase space of a particle moving on the line, is derived from the resolution of the unity provided by the standard (or gaussian) coherent states ...
J. P. Gazeau, M. C. Baldiotti, D. M. Gitman   +2 more
doaj  

A moment problem [PDF]

Journal of the Australian Mathematical Society, 1965
Let ν be a discrete random variable taking on nonnegative integer values and set P{ν = κ} = Pk, κ = 0, 1, hellip. Suppose that the binomial moments are finite. Frequently the problem arises under what conditions the probabilities Pk, k = 0, 1,…, can be determined uniquely by the sequence of moments Br, r = 0, 1,…, and how it can be done.
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source