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Electrophysiological effects of monensin, a sodium ionophore,on cardiac

European Journal of Pharmacology, 1990
Abstract Monensin, a monovalent cation ionophore, transports sodium ions preferentially. We found that, in the cardiac Purkinje fibers, monensin 10−5 M increased the resting tension of the fiber bundle in Tyrode solution containing 4.5 mM Ca. This ionophore (10−5 M) shortened the duration of the action potential and suppressed the pacemaker potential.
Susumu Ōtomo
exaly   +2 more sources

Stimulation of glucose transport in skeletal muscle by the sodium ionophore monensin

Biochimica Et Biophysica Acta - Biomembranes, 1985
The tissue/medium distribution of the nonmetabolized glucose analog 3-O-methyl-D-glucose was measured in mouse diaphragm muscle and related to changes in 45Ca influx, Na+ content and Na+-pump activity. In the presence of external Ca2+ the sodium ionophore monensin greatly increased cellular Na+ content (and decreased K+ content) although 86Rb uptake ...
P C Sawh, I Bihler
exaly   +3 more sources

The action of the sodium ionophore, monensin, on transmitter release at the frog neuromuscular junction

Brain Research, 1981
The action of the sodium ionophore, monensin, on spontaneous and evoked transmitter release at the frog neuromuscular junction was studied. Ringer's solutions with low calcium concentrations (0.4 mM or 0 Ca 1 mM EGTA) were used to bathe the preparation.
R Rahamimoff   +2 more
exaly   +3 more sources

The effect of sodium monensin on pregnant ewes

British Veterinary Journal, 1985
Abstract Sodium monensin (monensin) was fed to ewes during late pregnancy. Food intake, live-weight change and lamb birth-weights were recorded. Blood samples were obtained for estimation of glucose, β-hydroxybutyrate, albumin and urea. Ewes significantly reduced their food intake in response to treatment with sodium monensin and lost more live ...
A R, Austin, R M, Wilde
openaire   +2 more sources

Delayed monensin sodium toxicity in horses

Equine Veterinary Journal, 1981
Summary Thirty‐two horses were examined with a history of poor performance and unthriftiness several months after the ingestion of feed containing monensin sodium. Cardiac abnormality was diagnosed in 8 cases and suspected in 4 others. Necropsy examinations were performed on 6 cases with marked clinical symptoms
E, Muylle   +4 more
openaire   +2 more sources

Accidental monensin sodium intoxication of feedlot cattle

Journal of the American Veterinary Medical Association, 1984
Summary Of 1,994 yearling and 2-year-old cattle in a winter feeding program, 117 died within 42 days of being fed toxic amounts of monensin sodium in a liquid protein supplement. Death losses commenced on the third day after ingestion of a toxic amount in the feed. Clinical signs in cattle that died in less than 9 days included anorexia, pica, diarrhea,
D, Schweitzer   +4 more
openaire   +2 more sources

Comparative Toxicology of Monensin Sodium in Laboratory Animals

Journal of Animal Science, 1984
The toxicology of monensin has been studied in several laboratory animal species. There was considerable species variation in acute oral LD50 values. The consistent signs of acute toxicity were: anorexia, hypoactivity, skeletal muscle weakness, ataxia, diarrhea, decreased weight gain and delayed deaths. The 3-mo study in rats fed diets containing 0, 50,
G C, Todd, M N, Novilla, L C, Howard
openaire   +2 more sources

ADAPTATION OF RUMEN BACTERIA TO SODIUM AND MONENSIN

Canadian Journal of Animal Science, 1984
Rumen bacteria were able to adapt to concentrations of Na+ > 300 mM. This is higher than that normally found in the rumen (< 200 mM Na+). In chemostat culture both Selenomonas ruminantium and Ruminococcus albus adapted to the effects of Na+ and monensin. Substrate yields slowly decreased before reaching steady state values.
R. I. MACKIE, P. G. BAHRS, J. J. THERION
openaire   +1 more source

Fasciola hepatica: the effect of the sodium inophore monensin on the adult tegument

Parasitology Research, 1989
The effect on the tegument of adult Fasciola hepatica of incubation in the sodium ionophore monensin, the Na+/K+-ATPase inhibitor ouabain and ouabain pretreatment followed by monensin has been determined in vitro by scanning and transmission electron microscopy (SEM, TEM). With monensin incubation alone (1 x 10(-6) M), a flattening of the tegument with
Skuce, P.J., Fairweather, Ian
openaire   +2 more sources

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