Results 131 to 140 of about 26,362,079 (261)
Frontiers in Mechanical EngineeringThe analysis of monitoring data plays a critical role in dam safety assessment. The data analysis process typically involves three stages: monitoring point information inspection, single-point analysis and early warning, and multi-point data fusion and ...
Yanpian Mao +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
LSTM-Based Performance Prediction of Reciprocating Seals for Aircraft High-Pressure Actuators
LubricantsThe reciprocating dynamic sealing system is crucial for the operational reliability of aircraft high-pressure hydraulic actuators, particularly for civil aircraft with 21 MPa (e.g., B737, A320) and 35 MPa (e.g., B787, A380) pressure systems, where real ...
Wenjun Yu +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Two-stage assessment of regional geological hazard susceptibility under mining disturbance
Progress in Disaster ScienceMining disturbs regional environments and triggers geological hazards. Existing studies rely on conventional topographic and geological factors, neglecting quantitative mining disturbance analysis and its evolutionary impact.
Jufang Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Catchment characteristics and water chemistry of over 5000 nationally monitored Swedish lakes
Environmental Research CommunicationsLake water quality reflects interactions between in-lake processes and catchment-scale drivers, yet integrated datasets that combine lake chemistry with spatially explicit catchment information remain limited.
Anna Lackner +4 more
doaj +1 more source