The Infectious Diseases Consequences of Monkey Business [PDF]
Canadian Journal of Infectious Diseases and Medical Microbiology, 2008 Many microorganisms that affect humans have originated in animal species and have subsequently evolved to afflict humans (1). Many factors may contribute to the ability of infectious agents to cross the species barrier and include those related to the host, the pathogen and the host-pathogen environment.
JM Conly, BL Johnston
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Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing
Protein & Cell, 2020 Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors
Fang Wang +17 more
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Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach. [PDF]
PLoS ONE, 2015 Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins.
Katharina Debowski +8 more
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Introducing human 3D skin models as a new serological diagnostic tool for severe autoimmune bullous diseases [PDF]
Frontiers in ImmunologyAutoimmune bullous diseases (AIBDs) are acquired disorders characterized by autoantibodies targeting structural proteins of the skin and mucous membranes, resulting in blister formation.
Laura Huth +13 more
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Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? [PDF]
PLoS ONE, 2011 BACKGROUND: Non-human primates (NHP) are now being considered as models for investigating human metabolic diseases including diabetes. Analyses of cholesterol and triglycerides in plasma derived from NHPs can easily be achieved using methods employed in ...
Guanghou Shui +7 more
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A single-cell transcriptomic landscape of primate arterial aging
Nature Communications, 2020 Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited.
Weiqi Zhang +19 more
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Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia [PDF]
, 2015 Background The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths.
Chua, Tock H. +9 more
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Establishment of porcine and monkey colonic organoids for drug toxicity study
Cell Regeneration, 2021 Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses.
Haonan Li +7 more
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A draft map of rhesus monkey tissue proteome for biomedical research. [PDF]
PLoS ONE, 2015 Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains ...
Jin-Gyun Lee +9 more
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Sequence Analysis of Macaca mulatta TRIM4 and Its Role in the Interferon Pathway
Frontiers in Veterinary Science, 2022 Monkey diseases are becoming increasingly severe, and some may be transmitted to humans through direct and indirect contact. Innate immunity is the first line of defense against foreign microorganisms.
Mengmeng Zhao +5 more
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