Results 11 to 20 of about 67,538 (200)

Establishment of a novel cynomolgus monkey model of hyperuricemia [PDF]

Animal Models and Experimental Medicine
Background Chronic hyperuricemia is associated with complications such as gout and uric acid nephropathy, but uric acid also exhibits biological activities (e.g., antioxidant effects, potential neuroprotective properties against neurodegenerative ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
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Terahertz Spectroscopic Diagnosis of Myelin Deficit Brain in Mice and Rhesus Monkey with Chemometric Techniques

Scientific Reports, 2017
While myelin deficit of the central nervous system leads to several severe diseases, the definitive diagnostic means are lacking. We proposed and performed terahertz time-domain spectroscopy (THz-TDS) combined with chemometric techniques to discriminate ...
Yi Zou, Jiang Li, Yiyuan Cui, Peiren Tang, Lianghui Du, Tunan Chen, Kun Meng, Qiao Liu, Hua Feng, Jianheng Zhao, Mina Chen, Li-Guo Zhu   +11 more
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Establishment of a Rapid Lesion-Controllable Retinal Degeneration Monkey Model for Preclinical Stem Cell Therapy

Cells, 2020
Background: Retinal degenerative disorders (RDs) are the main cause of blindness without curable treatment. Our previous studies have demonstrated that human-induced pluripotent stem cells can differentiate into retinal organoids with all subtypes of ...
Guanjie Gao, Liwen He, Shengxu Liu, Dandan Zheng, Xiaojing Song, Wenxin Zhang, Minzhong Yu, Guangwei Luo, Xiufeng Zhong   +8 more
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Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases

BMC Biotechnology, 2019
Background Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision and efficiency offered by engineered site ...
Chu Chu, Zhaohui Yang, Jiayin Yang, Li Yan, Chenyang Si, Yu Kang, Zhenzhen Chen, Yongchang Chen, Weizhi Ji, Yuyu Niu   +9 more
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Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey [PDF]

Frontiers in Pharmacology
The blood-brain barrier (BBB) formed by the cerebral microvessel endothelium and the blood-CSF barrier (BCSFB) formed by the choroid plexus epithelium impact the cerebral bioavailability of drugs and endogenous molecules that contribute to ...
Nathalie Strazielle, Nathalie Strazielle, Sandrine Blondel, Joachim Confais, Rita El Khoury, Hugues Contamin, Jean-François Ghersi-Egea   +6 more
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Sequence Analysis of Macaca mulatta TRIM4 and Its Role in the Interferon Pathway

Frontiers in Veterinary Science, 2022
Monkey diseases are becoming increasingly severe, and some may be transmitted to humans through direct and indirect contact. Innate immunity is the first line of defense against foreign microorganisms.
Mengmeng Zhao, Huawei Li, Hang Zhang, Huiyang Sha, Liangzong Huang, Ruining Wang   +5 more
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Heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by scRNA-seq analysis and trajectory inference

Scientific Reports, 2022
The frequency of CD4+CD8+ double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous ...
Sung Min Choi, Hi Jung Park, Eun A Choi, Kyeong Cheon Jung, Jae Il Lee   +4 more
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Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging

Frontiers in Cell and Developmental Biology, 2021
Vascular aging is a potent driver of cardiovascular and cerebrovascular diseases. Vascular aging features cellular and functional changes, while its molecular mechanisms and the cell heterogeneity are poorly understood.
Fei Ge, Qi Pan, Yue Qin, Mengping Jia, Chengchao Ruan, Xiangxiang Wei, Qing Jing, Xiuling Zhi, Xinhong Wang, Lindi Jiang, Elena Osto, Jieyu Guo, Dan Meng   +12 more
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The basic reproductive ratio of the 2022 outbreak of the monkey pox virus disease for the United Kingdom, Canada, Brazil, the United Arab Emirates, and Nigeria

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background A recent outbreak of the monkey pox virus disease (MPVD) started to spread over the world before the second half of the 2022 year. This outbreak of the monkey pox virus disease is known as the 2022 outbreak of the monkey pox virus disease. The
Marwan Al-Raeei
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Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate

Frontiers in Aging Neuroscience, 2022
Because of the difficulty in collecting fresh brains of humans at different ages, it remains unknown how epigenetic regulation occurs in the primate brains during aging.
Yanru Xu, Liying Zhong, Huixian Wei, Yuwei Li, Jiaxiang Xie, Leijie Xie, Xiusheng Chen, Xiangyu Guo, Peng Yin, Shihua Li, Junwei Zeng, Xiao-Jiang Li, Li Lin   +12 more
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