Results 181 to 190 of about 67,779 (299)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Reported Cases and Deaths of National Notifiable Infectious Diseases - China, March 2026. [PDF]

China CDC Wkly
europepmc   +1 more source

Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys. [PDF]

Int J Biol Sci
Song X, Li C, Yang Y, Huang C, Chen M, Lin S, Huang Z, Wang W, Liao K, Wei H, Wang L, Xu H, Chen Y, Lin Y, Li J, Dai Z, Xie W, Zheng X, Wu J, Gao J, Wu J, Tu Z, Zhou L, Huang L, Ren C, So KF, Yin P, Yang H, Li S, Lai L, Li XJ, Yan S.   +31 more
europepmc   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Reported Cases and Deaths of National Notifiable Infectious Diseases - China, April 2026. [PDF]

China CDC Wkly
europepmc   +1 more source

A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 3: from lead towards a drug development candidate. [PDF]

J Antimicrob Chemother
Hendrickx S, Ilbeigi K, Thoré ESJ, Bertram MG, Calvo-Alvarez E, Cintesun S, Olías-Molero AI, Corral MJ, Mateo-Barrientos M, Estaquier J, Pomel S, Alunda JM, Gul S, Van Bocxlaer K, Frézard F, Tavares J, Cordeiro Da Silva A, Costi MP, Maes L, Caljon G.   +19 more
europepmc   +1 more source

Oral GLP‐1RA TERN‐601 for Adults With Obesity/Overweight: Placebo‐Controlled, Multiple‐Ascending‐Dose, Phase 1 and 2 Studies

Obesity, EarlyView.
ABSTRACT Objective The safety, tolerability, pharmacokinetics, and efficacy of TERN‐601, a once‐daily, oral small‐molecule glucagon‐like peptide‐1 (GLP‐1) receptor agonist, were studied in Phase 1 and 2 clinical studies. Methods The Phase 1 (28‐day) and Phase 2 (12‐week), randomized, double‐blind, placebo‐controlled, multiple‐ascending‐dose studies ...
W. Timothy Garvey, Julio Rosenstock, Harold E. Bays, Douglas Denham, Anita Kohli, Melanie Haines, Christopher Jones, Ellen Kwan, Erin Castelloe, Tonya Marmon, Emil Kuriakose, Cara Nelson   +11 more
wiley   +1 more source

Characterization of a Long-Acting Anti-Human MASP-2 Antibody for the Treatment of Complement-Related Diseases. [PDF]

J Inflamm Res
Han X, Yang C, Wang Z, Fan K, Liu K, Ye H, Zhang W, Zhang J, Hu X, Lin H, Liao C.   +10 more
europepmc   +1 more source

Congenital Intraoral Synechiae: A Scoping Review of Airway, Feeding, and Surgical Management

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To map the existing literature on congenital intraoral synechiae and summarize reported anatomic patterns, clinical presentation, associated anomalies/syndromes, and outcomes to inform standardized diagnostic and therapeutic approaches. Data Sources PubMed, CINAHL, Embase, Web of Science, and Google Scholar were searched from January
Jason Bernier, Mathieu Bergeron
wiley   +1 more source

Reported Cases and Deaths of National Notifiable Infectious Diseases - China, February 2026. [PDF]

China CDC Wkly
europepmc   +1 more source