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An immunoinformatic approach towards development of a potent and effective multi-epitope vaccine against monkeypox virus (MPXV)

Journal of Biomolecular Structure and Dynamics, 2023
Monkeypox is a viral zoonotic disease, often transmitted to humans from animals. While the whole world is haggling with the COVID-19 pandemic, the emergence of the monkeypox virus (MPXV) arose as a new challenge to mankind. Till date, numerous cases related to the MPXV have been reported in several countries across the globe, but, its momentary ...
Sanghamitra Pati, Budheswar Dehury
exaly   +3 more sources

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Monkeypox Virus (MPXV) Infection: A Review

Infectious Disorders - Drug Targets
Abstract: Monkeypox is a viral disease; its outbreak was recently declared a global emergency by the World Health Organization. For the first time, a monkeypox virus (MPXV)-infected patient was found in India. Various researchers back-to-back tried to find the solution to this health emergency just after COVID-19.
J P Yadav, Ratish Chandra Mishra
exaly   +3 more sources

Defining antigen targets to dissect vaccinia virus (VACV) and Monkeypox virus (MPXV)-specific T cell responses in humans

2022
Abstract The current Monkeypox virus (MPXV) outbreak in non-endemic countries is raising concern about the pandemic potential of novel orthopoxviruses. Little is known regarding MPXV immunity in the context of MPXV infection or vaccination with Vaccinia-based vaccines (VACV).
Alba Grifoni, Yun Zhang, Alison Tarke, John Sidney, Paul Rubiro, Maria Reina-Campos, Gilberto Filaci, Jennifer Dan, Richard H. Scheuermann, Alessandro Sette   +9 more
openaire   +1 more source

An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

Chinese Chemical Letters
Shaobo Ruan, Yuanyu Huang, Haiyin Yang   +2 more
exaly   +2 more sources

Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus [PDF]

Virology, 2009
Suitable animal models are needed to study monkeypox virus (MPXV) as human monkeypox clinically resembles smallpox and MPXV is a zoonotic and potential bioterroristic agent.
David L Huso, R Mark L Buller
exaly   +2 more sources

Targeting monkeypox virus (MPXV): strategies for molecular docking studies on protein inhibition

Virus Genes
In the year 2022, the outbreak of monkeypox virus (MPXV) occurred in the various countries of Africa, particularly Central and West Africa, North America, South America, Europe, and other countries. Without any delay it spread across more than 100 countries infecting around 116,015 people causing around 255 deaths.
Jayant Murlidhar, Kushwaha, Majji Sai Sudha, Rani, Shilpy, Singh   +2 more
openaire   +2 more sources

Structural and molecular investigation of the impact of S30L and D88N substitutions in G9R protein on coupling with E4R from Monkeypox virus (MPXV)

Journal of Biomolecular Structure and Dynamics
Understanding the pathogenesis mechanism of the Monkeypox virus (MPXV) is essential to guide therapeutic development against the Monkeypox virus. In the current study, we investigated the impact of the only two reported substitutions, S30L, D88N, and S30L-D88N on the G9R of the replication complex in 2022 with E4R using structural modeling, simulation,
Abbas Khan, Yifan Jin, Yasir Waheed
exaly   +3 more sources

Review of virological methods for laboratory diagnosis and characterization of monkeypox virus (MPXV): lessons learned from the 2022 Mpox outbreak

Acta Dermatovenerologica Alpina Pannonica et Adriatica
Monkeypox virus (MPXV), originally endemic in West Africa (Clade II) and Central Africa (Clade I), has recently emerged worldwide and has reinforced the need for rapid and accurate MPXV diagnostics. This review presents and critically discusses the range of virological methods for laboratory diagnosis and characterization of MPXV as well as related ...
Katarina, Resman Rus, Samo, Zakotnik, Martin, Sagadin, Marko, Kolenc, Lucijan, Skubic, Nataša, Knap, Misa, Korva, Mario, Poljak, Tatjana, Avšič-Županc   +8 more
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Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology

Research Journal of Pharmacy and Technology
Infection with a DNA virus called monkeypox virus (MPXV) in humans has been identified in the Congo since 1970. Antiviral drugs are not effective for preventing MPXV infection. MPXV infection cases in Indonesia are very low but MPXV has the potential to become a global pandemic so it is very important to do prevention such as vaccine development.
Viol Dhea Kharisma, A. N. M. Ansori, Ahmad Affan Ali Murtadlo, Muhammad Hermawan Widyananda, Md. Emdad Ullah, Sin War Naw, Vikash Jakhmola, Kiran Dobhal, Tarun Parashar, Maksim Rebezov, Rahadian Zainul   +10 more
openaire   +1 more source

Unnoticed Entry, Noticed Transmission: Epidemiological Insights into China's First Clade Ib Monkeypox Virus Cluster

The Journal of Infectious Diseases
Abstract Background The mpox outbreak caused by Clade Ib monkeypox virus (MPXV) spread rapidly in Central and East Africa and led the World Health Organization to declare the outbreak a public health emergency of international concern (PHEIC).
Xin Ye, Peng He, Baiyun Yu, Conghua Bai, Jingmin Chen, Qin Liu, Mingming Jiang, Minjie Xiang, Weiwen Guo, Mingqiang Huang, Yiyan Feng, Xiaoliang Guo, Zaiyou Dai, Naling Zhu, Yanjun Chen, Cuihua Fan, Hetao Wang, Tiantian Yin, Yinglin Lin, Duoji Fan, Dongmei Chen, Yuqi Chen, Erbao Bao, Liqing He, Jueyu Wu, Kaibin Wang, Zhigang Han, Wenzhe Su, Bosheng Li, Ximing Huang, Wenfeng Cai   +30 more
openaire   +2 more sources