Results 181 to 190 of about 11,083 (203)
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A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling
Current Medicinal Chemistry, 2010Together with anandamide, 2-arachidonoylglycerol (2-AG) constitutes one of the main representatives of a family of endogenous lipids known as endocannabinoids. These act by binding to CB(1) and CB(2) cannabinoid receptors, the molecular target of the psychoactive compound Delta(9)-THC, both in the periphery and in the central nervous system, where they
Labar, G., Wouters, J., Lambert, D. M.
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The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress
Cell Biochemistry and Biophysics, 2014In recent years, metabolism is talked highly important in cancer research, especially the lipid metabolism. Researchers believe that the de novo fatty acid synthesis plays an important role in tumor development, while many studies illustrated that Endocannabinoids have anti-tumorigenic actions, including anti-proliferation, apoptosis induction, and ...
Hong, Qin, Zhi-hua, Ruan
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The Medicinal Chemistry of Agents Targeting Monoacylglycerol Lipase
Current Topics in Medicinal Chemistry, 2008Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological ...
Alma, Viso +2 more
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Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system
Biotechnology Letters, 2003The 1,3-regiospecifique lipase, Lipozyme IM, catalyzed the esterification of lauric acid and glycerol in a homogeneous system. To overcome the drawback of the insolubility of glycerol in hexane, which is extensively used in enzymatic synthesis, a mixture of n-hexane/tert-butanol (1:1, v/v) was used leading to a monophasic system.
Julieta B, Monteiro +2 more
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Lipase-catalyzed syntheses of monoacylglycerols
Enzyme and Microbial Technology, 1995The application of lipases for the production of monoacylglycerols is reviewed. Glycerolysis or selective hydrolysis of fats and oils, esterification of fatty acids or esters with glycerol, and reactions employing protected glycerols are presented. From the most recent literature, reaction systems ranging from organic solvents to reverse micelles and ...
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Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis
Medical Hypotheses, 2019Interstitial cystitis is a chronic inflammatory condition of the urinary bladder with an unclear etiology. Currently, there are no widely accepted long-term treatment options available for patients with IC, with the European Association of Urology (EAU, 2017 guidelines), American Urology Association (AUA, 2014 guidelines), and the Royal College of ...
Anu, Chinnadurai +6 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981
We report here that both the hepatic lipase and lipoprotein lipase demonstrate specificity towards the acyl group present on monoacylglycerols. We found that unsaturated glycerides are more readily degraded than saturated glycerides. However, the basis for this specificity appears to be different for each enzyme. The activity of the hepatic lipase, but
C H, Miller +3 more
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We report here that both the hepatic lipase and lipoprotein lipase demonstrate specificity towards the acyl group present on monoacylglycerols. We found that unsaturated glycerides are more readily degraded than saturated glycerides. However, the basis for this specificity appears to be different for each enzyme. The activity of the hepatic lipase, but
C H, Miller +3 more
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An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)
Expert Opinion on Therapeutic Patents, 2021Giulia Bononi +2 more
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