Results 31 to 40 of about 5,459 (175)

Development of a versatile laboratory experiment to teach the metabolic transformation of hydrolysis [PDF]

, 2016
In this paper we describe an easy, reliable, versatile and inexpensive laboratory experiment to teach the metabolic transformation of hydrolysis to Pharmacy students.
Badyal, D.K., Desai, C., Bailey, D.G., Dresser, G., Arnold, J.M.O., Bailey, D.G., Malcolm, J., Arnold, O., Spence, J. D., Barry, E., Borer, L., Bemback, S., Blackberg, L., Hemell, O., Braiuca, P., Lorena, K., Ferrario, V., Ebert, C., Gardossia, L., Clay, M.D., McLeod, E.J., Fojan, P., Jonson, P.H. Petersen, M.T.N., Steffen B., Petersen, S.B., Fuentes, G., Ballesteros, A., Verma, C.S., Fukami, T., Yokoi, T., Herrier, R.N., Jackson, T.R., Consroe, P.F., Mattson, F.H., Beck, L.W., Ogu, C.C., Maxa, J.L., Qayed, W.S., Aboraia, A.S., Abdel-Rahman, H.M., Youssef, A.F., Rautio, J., Kumpulainen, H., Heimbach T., Oliyai, R., Oh, D., Järvinen, T., Savolainen, J., Rengachari, S., Aschauer, P., Schittmayer, M., Mayer, N., Gruber, K., Breinbauer, R., Birner-Gruenberger, R., Dreveny, I., Oberer, M., Toone, E.J., Werth, M.J., Jones, J.B., Ward, L.C., Reilly, P.E.B.   +17 more
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A First Attempt into the Production of Acylglycerol Mixtures from Echium Oil [PDF]

, 2016
Enzymatic glycerolysis of Echium oil (Echium plantagineum) has been carried out in the presence of four commercial lipases. Different pretreatments of the reaction mixture, such as high pressure homogenization and addition of food grade monoolein as an ...
Alejandro eJordán, Carlos F Torres, Guillermo eReglero, Guillermo eReglero, Luis eVázquez   +4 more
core   +3 more sources

N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase

Biotechnology for Biofuels, 2019
Background Lipolytic enzymes of hyperthermophilic archaea generally prefer small carbon chain fatty acid esters (C2–C12) and are categorized as esterases.
Surabhi Soni, Sneha S. Sathe, Rutuja R. Sheth, Prince Tiwari, Rajesh-Kumar N. Vadgama, Annamma Anil Odaneth, Arvind M. Lali, Sanjeev K. Chandrayan   +7 more
doaj   +1 more source

Discrimination against diacylglycerol ethers in lipase-catalysed ethanolysis of shark liver oil [PDF]

, 2013
This is the author’s version of a work that was accepted for publication in Food Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Fernández, Óscar, Reglero, Guillermo, Torres, Carlos F., Vázquez, Luis Nuñez   +3 more
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Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors [PDF]

Chemistry & Biology, 2009
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Previous efforts to design MGL inhibitors have focused on chemical scaffolds that irreversibly block the activity of this enzyme.
KING AR, DOTSEY EY, JUNG KM, GHOMIAN A, QIU Y, FU J, PIOMELLI D., LODOLA, Alessio, MOR, Marco   +8 more
openaire   +3 more sources

Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease [PDF]

, 2014
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of metabolic abnormalities ranging from simple hepatic steatosis (accumulation of neutral lipid) to development of steatotic lesions, steatohepatitis, and cirrhosis.
Finck, Brian N, Schweitzer, George G
core   +3 more sources

Inhibitors of monoacylglycerol lipase as novel analgesics [PDF]

British Journal of Pharmacology, 2007
2‐Arachidonoylglycerol (2‐AG) is an endogenous cannabinoid (endocannabinoid) lipid whose functions remain poorly understood. Guindon and colleagues report the novel finding that exogenous application of 2‐AG induces peripheral antinociceptive effects that are mediated, at least in part, by actions at peripheral cannabinoid CB2 receptors.
openaire   +2 more sources

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase [PDF]

Journal of Biological Chemistry, 2013
Monoacylglycerol lipases (MGLs) play an important role in lipid catabolism across all kingdoms of life by catalyzing the release of free fatty acids from monoacylglycerols. The three-dimensional structures of human and a bacterial MGL were determined only recently as the first members of this lipase family.
Rengachari S., Aschauer P., Schittmayer M., Mayer N., Gruber K., Breinbauer R., Birner-Gruenberger R., Dreveny I., Oberer M.   +8 more
openaire   +3 more sources

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

Journal of Medicinal Chemistry, 2022
Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols. Many studies demonstrated beneficial effects deriving from MAGL inhibition for neurodegenerative diseases, inflammatory pathologies, and cancer.
Giulia Bononi, Miriana Di Stefano, Giulio Poli, Gabriella Ortore, Philip Meier, Francesca Masetto, Isabella Caligiuri, Flavio Rizzolio, Marco Macchia, Andrea Chicca, Amir Avan, Elisa Giovannetti, Chiara Vagaggini, Annalaura Brai, Elena Dreassi, Massimo Valoti, Filippo Minutolo, Carlotta Granchi, Jürg Gertsch, Tiziano Tuccinardi   +19 more
openaire   +5 more sources

Acetyl-11-keto-β-boswellic acid alleviates hepatic metabolic dysfunction by inhibiting MGLL activity

Journal of Lipid Research
Metabolic abnormalities have emerged as a central pathogenesis in various metabolic diseases, particularly nonalcoholic fatty liver disease (NAFLD) and its associated complications of obesity and insulin resistance. Despite this, effective pharmaceutical
Kai Luan, Yuhong Fan, Qin Yang, Hailong Yang, Zelin Zhou, Ju Huang, Zhigang She, Toujun Zou, Hui Xiong, Zhinan Mei   +9 more
doaj   +1 more source