Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. [PDF]
, 2012 Facoltà di Farmacia Corso di laurea in Chimica e tecnologia farmaceutica; Relatore: prof.ssa C.Manera, dott.ssa F.Castelli; SSD: CHIM 08 Candidato: Gianfilippo Martello Titolo tesi: Design, synthesis and biological evaluation of heterocyclic derivatives ...
MARTELLO, GIANFILIPPO
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Cancer metabolism at a glance [PDF]
, 2016 A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal +5 more
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Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators [PDF]
ACS Medicinal Chemistry Letters, 2022 openaire +2 more sources
, 2012 We report that the hydrolytic performance of Thermomyces lanuginosus lipase, TLL, and its selectivity towards concentrating clinically important omega 3 fatty acids was increased by the addition of a protic ionic liquid, pIL, Triethylammonium mesylate ...
Akanbi, Taiwo O. +2 more
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From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System. [PDF]
, 2010 There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Abel +125 more
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A novel live cell assay to measure diacylglycerol lipase α activity [PDF]
, 2016 Diacylglycerol lipase α (DAGLα) hydrolyses DAG to generate the principal endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) in the central nervous system.
Doherty, Patrick +4 more
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PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. [PDF]
, 2009 The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3-12, and OXPAT.
Bickel, Perry E +2 more
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Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors [PDF]
, 2016 Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to alleviate pain and inflammation, regulate motility and appetite, and produce anti-cancer, anxiolytic, and neuroprotective efficacies via cannabinoid receptor type 1 (CB1) or ...
Chavatte, Philippe +5 more
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Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. [PDF]
, 2015 Perilipin 1 is a lipid droplet coat protein predominantly expressed in adipocytes, where it inhibits basal and facilitates stimulated lipolysis. Loss-of-function mutations in the PLIN1 gene were recently reported in patients with a novel subtype of ...
Barroso, I +15 more
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Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2021 openaire +2 more sources