Results 61 to 70 of about 3,551 (187)

Assessment of a Spectrophotometric Assay for Monoacylglycerol Lipase Activity

The AAPS Journal, 2010
Endocannabinoids are lipid-signaling molecules that bind cannabinoid receptors. These G-protein-coupled receptors were discovered as binding sites for Δ9-tetrahydrocannabinol (THC), the psychoactive component of marijuana (Cannabis sativa) (1). Two types of cannabinoid receptors are known: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2 ...
Nadine M, Ulloa, Dale G, Deutsch
openaire   +3 more sources

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

Cell Reports, 2012
Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression. Monoacylglycerol lipase (MAGL) is the primary enzyme metabolizing the endocannabinoid 2-arachidonoylglycerol in the brain.
Chen, Rongqing, Zhang, Jian, Wu, Yan, Wang, Dongqing, Feng, Guoping, Tang, Ya-Ping, Teng, Zhaoqian, Chen, Chu   +7 more
openaire   +5 more sources

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Produção de monoacilgliceróis e diacilgliceróis ricos em ácidos graxos ômega-3 a partir da glicerólise enzimática de óleo de peixe [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2011O objetivo deste estudo foi apresentar novas informações experimentais para a obtenção de ...
Feltes, Maria Manuela Camino
core  

The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition

, 2018
Monoacylglycerol lipases (MGLs) are enzymes that hydrolyze monoacylglycerol into a free fatty acid and glycerol. Fatty acids can be used for triacylglycerol synthesis, as energy source, as building blocks for energy storage, and as precursor for membrane
Monika Oberer, Tea Pavkov-Keller, Philipp Aschauer, Robert Zimmermann, Rolf Breinbauer   +4 more
core   +1 more source

Characterization of a monoacylglycerol lipase in the medicinal leech, Hirudo verbana

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2020
Endocannabinoids are a class of lipid neuromodulators found throughout the animal kingdom. Among the endocannabinoids, 2-arachydonoyl glycerol (2-AG) is the most prevalent endocannabinoid and monoacylglycerol lipase (MAGL) is a serine hydrolase primarily responsible for metabolizing 2-AG in mammals. In the medicinal leech, Hirudo verbana, 2-AG has been
Emily, Kabeiseman, Riley, Paulsen, Brian D, Burrell   +2 more
openaire   +3 more sources

Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer [PDF]

Journal of Obstetrics and Gynaecology Research, 2019
AbstractAimAbnormal lipid metabolism plays a dual role in tumorigenesis, specifically in the occurrence and development of cancers. Monoacylglycerol lipase (MAGL), a hydrolase that is important for lipid metabolism, plays a vital role in different aspects of tumorigenesis. Many studies have shown that MAGL is highly elevated in a variety of cancers and
Xin Li, Shuhong Gao, Wenzhi Li, Zhiming Liu, Zhengzheng Shi, Chunping Qiu, Jie Jiang   +6 more
openaire   +2 more sources