SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy [PDF]
Communications Biology, 2023 Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA).
Valeria Valsecchi +14 more
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Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation. [PDF]
Proc Natl Acad Sci U S A, 2017 SignificanceHuman cytosolic sulfotransferases (SULTs) regulate hundreds of signaling small molecules, yet little is known regarding their small-molecule regulation. Members of the SULT1 family harbor a conserved allosteric site that we hypothesize allows independent regulation of sulfonation in the 11 metabolic areas in which these isoforms operate ...
Cook I, Wang T, Leyh TS.
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Analysis of Catecholamines and Pterins in Inborn Errors of Monoamine Neurotransmitter Metabolism—From Past to Future [PDF]
Cells, 2019 Inborn errors of monoamine neurotransmitter biosynthesis and degradation belong to the rare inborn errors of metabolism. They are caused by monogenic variants in the genes encoding the proteins involved in (1) neurotransmitter biosynthesis (like tyrosine
Sabine Jung-Klawitter +1 more
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Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder [PDF]
Frontiers in Psychiatry, 2020 Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies.
Xiaojun Shao, Gang Zhu, Gang Zhu
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Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. [PDF]
Pharmacol Rev, 2016 Modulation of neurotransmission by the monoamines dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is critical for normal nervous system function. Precise temporal and spatial control of this signaling in mediated in large part by the actions of monoamine transporters (DAT, NET, and SERT, respectively). These transporters act to recapture their
Bermingham DP, Blakely RD.
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Neurotransmitter recognition by human vesicular monoamine transporter 2
Nature CommunicationsHuman vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a crucial role in regulating neurotransmitters in the brain by facilitating their uptake and storage within vesicles, preparing them for exocytotic release.
Dohyun Im +11 more
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Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models [PDF]
Journal of Ovarian ResearchPolycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Tingting Mo +11 more
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Clinical features and pharmacotherapy of childhood monoamine neurotransmitter disorders. [PDF]
Paediatr Drugs, 2014 Childhood neurotransmitter disorders are increasingly recognised as an expanding group of inherited neurometabolic syndromes. They are caused by disturbance in synthesis, metabolism, and homeostasis of the monoamine neurotransmitters, including the catecholamines (dopamine, norepinephrine, and epinephrine) and serotonin.
Ng J, Heales SJ, Kurian MA.
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Monoamine neurotransmitters and mood swings: a dynamical systems approach
Mathematical Biosciences and Engineering, 2022 Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model
R. Loula, L. H. A. Monteiro
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Blood, urine and cerebrospinal fluid analysis in TH and AADC deficiency and the effect of treatment
Molecular Genetics and Metabolism Reports, 2021 Background: Aromatic L-amino acid decarboxylase (AADC) deficiency and tyrosine hydroxylase (TH) deficiency are rare inherited disorders of monoamine neurotransmitter synthesis which are typically diagnosed using cerebrospinal fluid examination of ...
Tessa Wassenberg +5 more
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