Personalizing Antidepressant Therapy: Integrating Pharmacogenomics, Therapeutic Drug Monitoring, and Digital Tools for Improved Depression Outcomes. [PDF]
J Pers MedParshenkov M +6 more
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5-HT<sub>1A</sub> receptor antagonism decreases motor activity and influences dopamine and serotonin metabolization pathways, primarily in cingulate cortex and striatum. [PDF]
Sci RepFazari B +13 more
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Pharmacology of monoamine neurotransmitter transporters
Folia Pharmacologica Japonica, 2002Following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, NET, DAT, and SERT, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, VMAT.
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Clinical investigation of monoamine neurotransmitter interactions
Psychopharmacology, 1993Monoamine neurotransmitter systems are widely thought to be involved in the pathophysiology of affective disorders and schizophrenia and the mechanism of action of antidepressant and antipsychotic drugs. Previous clinical studies have focused on individual monoamine function in isolation, even though a large number of preclinical studies have ...
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Regulation Of Enzymes That Synthesize Neurotransmitter Monoamines
Advances in Enzyme Regulation, 1976Abstract The synthesis of neurotransmitter amines (catecholamines and serotonin) appears to be closely coupled with the activity of neurons. Regulation of the synthesis of these monoamines occurs primarily at the first enzymatic step in their synthesis, i.e., tyrosine hydroxylase and tryptophan hydroxylase.
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Retention prediction of monoamine neurotransmitters in gradient liquid chromatography
Journal of Separation Science, 2022Retention prediction of monoamine neurotransmitters has been compared for the generally applied linear solvent‐strength model and quadratic polynomial three‐parameter model. The design of experiments protocol has been applied to plan linear gradients within the experimental space with altered gradient time, mobile phase flow rate, and column ...
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Diet, Monoamine Neurotransmitters and Appetite Control
2001This article has attempted to point out some of the relationships between 5-HT and catecholamine (NE, DA) neurons in brain and the control of appetite and food intake. At least two bodies of evidence support this connection. The first is pharmacologic, and demonstrates that drugs that stimulate transmission across 5-HT and/or catecholamine synapses ...
J D, Fernstrom, M H, Fernstrom
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Lithium and central monoamine neurotransmitter systems
Drug Development Research, 1983AbstractLithium salts have been in use in psychiatric medicine for the past three decades, but their mechanism of action is still unknown. Studies using a model of mania to delineate the means by which they exert their therapeutic effect have been hampered by the lack of a suitable animal analogue, although attempts have been made to induce a “manic ...
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Monoamine neurotransmitter disorders—clinical advances and future perspectives
Nature Reviews Neurology, 2015The monoamine neurotransmitter disorders are important genetic syndromes that cause disturbances in catecholamine (dopamine, noradrenaline and adrenaline) and serotonin homeostasis. These disorders result in aberrant monoamine synthesis, metabolism and transport.
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