Results 21 to 30 of about 25,801 (174)

SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine [PDF]

Molecular Aspects of Medicine, 2013
The exocytotic release of neurotransmitters requires active transport into synaptic vesicles and other types of secretory vesicles. Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine ...
Hakeem O, Lawal, David E, Krantz
openaire   +2 more sources

Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

eLife, 2022
Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-frequency synaptic transmission. Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc ...
Yongchao Han, Lei Peng, Tao Wang
doaj   +1 more source

Mutations in human monoamine-related neurotransmitter pathway genes [PDF]

Human Mutation, 2008
Biosynthesis and metabolism of serotonin and catecholamines involve at least eight individual enzymes that are mainly expressed in tissues derived from the neuroectoderm, e.g., the central nervous system (CNS), pineal gland, adrenal medulla, enterochromaffin tissue, sympathetic nerves, and ganglia.
Haavik, J, Blau, N, Thöny, B
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Monoamine Neurotransmitters and Drug Addiction

Science Insights, 2023
Drug addiction is a chronic, relapsing brain disease. Various addictive drugs act on the reward circuit and eventually cause changes in the release of neurotransmitters, resulting in a rewarding effect. Among them, the monoamine neurotransmitters 5-hydroxytryptamine, norepinephrine and dopamine play an essential role in drug addiction.
openaire   +1 more source

Fluorogenic Detection of Monoamine Neurotransmitters in Live Cells [PDF]

ACS Chemical Neuroscience, 2017
Monoamine neurotransmission is key to neuromodulation, but imaging monoamines in live neurons has remained a challenge. Here we show that externally added ortho-phthalaldehyde (OPA) can permeate live cells and form bright fluorogenic adducts with intracellular monoamines (e.g., serotonin, dopamine, and norepinephrine) and with L-DOPA, which can be ...
Kallol Bera, Anand Kant Das, Ananya Rakshit, Bidyut Sarkar, Anoop Rawat, Barun Kumar Maity, Sudipta Maiti   +6 more
openaire   +3 more sources

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment. [PDF]

Hum Brain Mapp
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Xu H, Li Y, Li C, Xu F, Liu Y, Yan K, Chen S, Song W, Luo Y, Li Y.   +9 more
europepmc   +2 more sources

Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model: mechanisms underlying orofacial allodynias and headache

Neural Regeneration Research, 2017
Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation.
Golam Mustafa, Jiamei Hou, Rachel Nelson, Shigeharu Tsuda, Mansura Jahan, Naweed S Mohammad, Joseph V Watts, Floyd J Thompson, Prodip Bose   +8 more
doaj   +1 more source

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes

Cell Reports, 2016
Monoamine and acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate insulin secretion in pancreatic islets. The molecular mechanisms controlling neurotransmitter signaling in islet β cells and their impact on diabetes ...
Elvira Ganic, Tania Singh, Cheng Luan, João Fadista, Jenny K. Johansson, Holly Ann Cyphert, Hedvig Bennet, Petter Storm, Gaëlle Prost, Henrik Ahlenius, Erik Renström, Roland Stein, Leif Groop, Malin Fex, Isabella Artner   +14 more
doaj   +1 more source

The Combination of Aquilaria sinensis (Lour.) Gilg and Aucklandia costus Falc. Volatile Oils Exerts Antidepressant Effects in a CUMS-Induced Rat Model by Regulating the HPA Axis and Levels of Neurotransmitters

Frontiers in Pharmacology, 2021
The Aquilaria sinensis (Lour.) Gilg (CX)–Aucklandia costus Falc. (MX) herbal pair is frequently used in traditional Chinese medicine prescriptions for treating depression.
Huiting Li, Yuanhui Li, Xiaofei Zhang, Guilin Ren, Liangfeng Wang, Jianzhe Li, Mengxue Wang, Tao Ren, Yi Zhao, Ming Yang, Ming Yang, Xiaoying Huang   +11 more
doaj   +1 more source

Combined Norepinephrine / Serotonergic Reuptake Inhibition: Effects on Maternal Behavior, Aggression and Oxytocin in the Rat

Frontiers in Psychiatry, 2011
BACKGROUND: Few systematic studies exist on the effects of chronic reuptake of monoamine neurotransmitter systems during pregnancy on the regulation of maternal behavior, although many drugs act primarily through one or more of these systems.
Elizabeth Thomas Cox, Thomas Merryfield Jarrett, Thomas Merryfield Jarrett, Matthew Stephen McMurray, Kevin eGreenhill, Vivian E Hofler, Sarah Kaye Williams, Paul Wayland Joyner, Christopher L Middleton, Cheryl H Walker, Josephine M Johns, Josephine M Johns, Josephine M Johns   +12 more
doaj   +1 more source