Results 51 to 60 of about 25,801 (174)

Monoamine transporters: Insights from molecular dynamics simulations

Frontiers in Pharmacology, 2015
The human monoamine transporters facilitate the reuptake of the neurotransmitters serotonin, dopamine, and norepinephrine from the synaptic cleft. Imbalance in monoaminergic neurotransmission is linked to various diseases including major depression ...
Julie eGrouleff, Lucy Kate Ladefoged, Heidi eKoldsø, Birgit eSchiøtt   +3 more
doaj   +1 more source

Mouse models for inherited monoamine neurotransmitter disorders

Journal of Inherited Metabolic Disease
AbstractSeveral mouse models have been developed to study human defects of primary and secondary inherited monoamine neurotransmitter disorders (iMND). As the field continues to expand, current defects in corresponding mouse models include enzymes and a molecular co‐chaperone involved in monoamine synthesis and metabolism (PAH, TH, PITX3, AADC, DBH ...
Beat Thöny, Joanne Ng, Manju A. Kurian, Philippa Mills, Aurora Martinez   +4 more
openaire   +4 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Validity of urinary monoamine assay sales under the “spot baseline urinary neurotransmitter testing marketing model”

International Journal of Nephrology and Renovascular Disease, 2011
Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, Neuro Research Clinics Inc, Cape Coral, FL; 2Stein Orthopedic Associates, Plantation, FL; 3Laboratory, Fairview Regional Medical Center-Mesabi, Hibbing, MN, USAAbstract: Spot baseline urinary ...
Hinz M, Stein A, Uncini T
doaj  

Cocaine modulates locomotion behavior in C. elegans.

PLoS ONE, 2009
Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter).
Alex Ward, Vyvyca J Walker, Zhaoyang Feng, X Z Shawn Xu   +3 more
doaj   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits

BMC Evolutionary Biology, 2019
Background Neurochemicals like serotonin and dopamine play crucial roles in human cognitive and emotional functions. Vesicular monoamine transporter 1 (VMAT1) transports monoamine neurotransmitters, and its variant (136Thr) is associated with various ...
Daiki X. Sato, Yuu Ishii, Tomoaki Nagai, Kazumasa Ohashi, Masakado Kawata   +4 more
doaj   +1 more source

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision

Cell Reports, 2019
Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
doaj   +1 more source

Effects of Fuhe decoction on behaviors and monoamine neurotransmitters in different brain regions of CUMS combined with social isolation depression model rats

Journal of Traditional Chinese Medical Sciences, 2020
Objective: To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation (CUMS) combined with social isolation.
Ruoyun Zheng, Weifeng Xiong, Juan He, Xu Wang, Ranran Wang, Yu Hao   +5 more
doaj   +1 more source