Getting the balance right: Established and emerging therapies for major depressive disorders
Neuropsychiatric Disease and Treatment, 2010 Bojana Perovic, Marija Jovanovic, Branislava Miljkovic, Sandra VezmarDepartment of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, SerbiaAbstract: Major depressive disorder (MDD) is a common and serious illness of our times, associated ...
Bojana Perovic +3 more
doaj
Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update
Food Science &Nutrition, Volume 14, Issue 2, February 2026.This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong +5 more
wiley +1 more source
Exploration of the Detailed Structure-Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors. [PDF]
ACS Omega, 2022 Kumar S +3 more
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity. [PDF]
Plants (Basel), 2023 Ayeni EA +5 more
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Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Inhibition of Monoamine Oxidases by Pyridazinobenzylpiperidine Derivatives
MoleculesMonoamine oxidase inhibitors (MAOIs) have been crucial in the search for anti-neurodegenerative medications and continued to be a vital source of molecular and mechanistic diversity.
Jong Min Oh +8 more
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Isatin-based benzyloxybenzene derivatives as monoamine oxidase inhibitors with neuroprotective effect targeting neurogenerative disease treatment. [PDF]
RSC Adv, 2023 Benny F +9 more
europepmc +1 more source
Subcutaneous Levodopa in Parkinson's Disease: A Systematic Review and Meta‐Analysis
European Journal of Neurology, Volume 33, Issue 2, February 2026.ABSTRACT Background Many Parkinson's disease patients receiving oral levodopa/carbidopa experience a troublesome wearing off effect. Higher doses to mitigate OFF‐time are limited by adverse effects occurring at peak dopamine levels, particularly dyskinesia.
Matthew Burton +6 more
wiley +1 more source