Results 141 to 150 of about 43,876 (205)

Navigating into the Chemical Space of Monoamine Oxidase Inhibitors by Artificial Intelligence and Cheminformatics Approach. [PDF]

ACS Omega, 2021
Kumar S, Nair AS, Bhashkar V, Sudevan ST, Koyiparambath VP, Khames A, Abdelgawad MA, Mathew B.   +7 more
europepmc   +1 more source

Multi‐Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders

Aging Cell, Volume 25, Issue 5, May 2026.
Integrating large‐scale human snRNA‐seq, spatial transcriptomics, and cerebral organoid datasets reveals cell‐type‐specific neurotransmitter‐system remodeling across aging and CNS disorders. Shared and disease‐specific NTS alterations highlight candidate mechanisms, sex differences, and exploratory discriminatory signals that may guide mechanistic ...
Rui‐Ze Niu, Meng‐Yuan Zhang, Yan‐Ping Li, Xiao‐Qian Zhou, Xiao‐Lei Liu, Jie Wu, Wei‐Wei Wang, Yan‐Jun Wang, Yi Ruan, Yu Ding, Xiao‐Feng Zeng, Tian‐Hao Bao   +11 more
wiley   +1 more source

Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action. [PDF]

Front Pharmacol, 2021
Ostadkarampour M, Putnins EE.
europepmc   +1 more source

DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization

Addiction Biology, Volume 31, Issue 5, May 2026.
This study employed integrative Mendelian Randomization analysis to identify 10 drug‐targetable genes with altered expression in alcohol dependence. Colocalization evidence suggests shared causal variants. Crucially, DNA methylation at specific sites (cg07437263, cg05102552) mediates risk by upregulating the protective gene CDK5R1 (63.92%) and ...
Fuyuan Deng, Junsheng Peng, Siran Lai, Guangpeng Zhang, Miaomiao Li, Yuxin Huang, Mi Yuan, Gaolei Yao, Peiming Zhang, Liming Lu   +9 more
wiley   +1 more source

Reduced Coupling of Global Brain Activity and Cerebrospinal Fluid Flow in Individuals With Betel Quid Dependence

Addiction Biology, Volume 31, Issue 5, May 2026.
Betel quid dependence (BQD) is a prevalent psychoactive substance‐use disorder with unclear neuropathology. Using resting‐state fMRI, we evaluated cerebral glymphatic function in BQD individuals by measuring the coupling between global BOLD and cerebrospinal fluid signals.
Li Li Fu, Chao Qi Lv, Li Ting Liu, Qing Qing Fu, Wei Yuan Huang, Yi Hao Guo, Tao Liu, Hui Juan Chen, Feng Chen   +8 more
wiley   +1 more source

Perioperative Treatment with High Dose Rotigotine and Amantadine Combination in a Patient with Advanced Stage Parkinson’s Disease After Esophagectomy

Acta Medica Bulgarica
Current treatment for Parkinson’s disease (PD) includes: levodopa, dopamine agonists, monoamine oxidase type B inhibitors, catechol-O-methyltransferase inhibitors, amantadine, anticholinergics, clozapine and deep brain stimulation. A lot of patients with
Yankov G., Ilieva V.
doaj   +1 more source

Chromenone Derivatives as Monoamine Oxidase Inhibitors from Marine-Derived MAR4 Clade Streptomyces sp. CNQ-031. [PDF]

J Microbiol Biotechnol, 2021
Oh JM, Lee C, Nam SJ, Kim H.
europepmc   +1 more source

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

Low 5HT1B and 5HT4 Receptor Neurotransmission as a Potential Link Between Cholesterol Metabolism and Suicide Risk

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Stress and inflammatory signals (e.g., IL‐6, TNFα, cortisol) may disrupt cholesterol metabolism and membrane microdomains known as lipid rafts. This can impair the function of serotonin receptors (5‐HT1B and 5‐HT4) that regulate impulsive behavior.
Hans O. Kalkman, Lukasz Smigielski
wiley   +1 more source

Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL‐1 Against Ischaemic/Hypoxic Stress

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Cristina Banfi, Lisa Brocca, Alice Bascucci, Giulia Giusy Papaianni, Alice Mallia, Sonia Eligini   +5 more
wiley   +1 more source