ABSTRACT Objective Bipolar disorder (BD) often emerges during mid‐adolescence and young adulthood, and leads to functional and social impairment, with a prevalence of 0.87% among Dutch youth. Lithium, the first‐line BD maintenance treatment, stabilizes mood, prevents suicide, and is well tolerated, yet its use has declined as long‐term second ...
Ravish N. Gangapersad +8 more
wiley +1 more source
Comparison of effectiveness and side effects of selegiline transdermal system versus oral monoamine oxidase inhibitors and tricyclic antidepressants for treatment-resistant depression. [PDF]
Kim TT, Xu C, Amsterdam JD.
europepmc +1 more source
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source
Design, Synthesis, and Biological Effect Studies of Novel Benzofuran-Thiazolylhydrazone Derivatives as Monoamine Oxidase Inhibitors. [PDF]
Osmani Ye D +9 more
europepmc +1 more source
Towards the Prevention of Freezing of Gait in Parkinson's Disease
Freezing of gait (FOG) is a disabling complication of Parkinson's disease (PD) that remains difficult to treat. Targeting modifiable risk factors and implementing pleiotropic (lifestyle) interventions before FOG onset may potentially delay or prevent its development.
Anouk Tosserams +3 more
wiley +1 more source
The open prospective multicenter INLEVO‐LIFE PD study showed in 40 patients with Parkinson's disease after 3 months of use of inhaled levodopa for OFF episodes an improvement in health‐related quality of life (primary endpoint) and also, as highlighted data, an effect of at least 90 min after its administration not only on motor status (UPDRS‐III) but ...
Diego Santos García +4 more
wiley +1 more source
<i>In Vitro</i> and <i>In Silico</i> ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases. [PDF]
Więckowska A +14 more
europepmc +1 more source
Catecholamines Activate a Tumour Progression Program in Differentiated Tumour Hepatocytes
ABSTRACT Background and Aims The sympathetic nervous system is involved in the progression and aggressiveness of several cancers, including hepatocellular carcinoma (HCC). However, the specific effects of sympathetic innervation and catecholamines on tumour hepatocyte behaviour remain poorly understood.
Elise Lelou +14 more
wiley +1 more source
Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings. [PDF]
Alborghetti M +5 more
europepmc +1 more source
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. [PDF]
Wang XB +5 more
europepmc +1 more source

