Results 21 to 30 of about 35,566 (181)

Inhibition of monoamine oxidases by benzimidazole chalcone derivatives

Applied Biological Chemistry, 2023
Ten benzimidazole chalcone derivatives were synthesized, and their monoamine oxidase (MAO) inhibitory activity was evaluated. Most compounds showed higher inhibitory activity against MAO-B than MAO-A.
Athulya Krishna, Jiseong Lee, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Prerna Uniyal, Leena K. Pappachen, Hoon Kim, Bijo Mathew   +7 more
doaj   +1 more source

Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action

Frontiers in Pharmacology, 2021
Chronic inflammatory diseases are debilitating, affect patients’ quality of life, and are a significant financial burden on health care. Inflammation is regulated by pro-inflammatory cytokines and chemokines that are expressed by immune and non-immune ...
Mahyar Ostadkarampour, Edward E. Putnins
doaj   +1 more source

Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]

, 2000
A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Bondy, Brigitta, Preuss, Ulrich W., Soyka, Michael, Hegerl, Ulrich, Benda, Ellen, Möller, Hans-Jürgen, Brigitta Bondy, Ulrich Preuss, Michael Soyka, Ellen Benda, Hans-Jürgen Möller, Ulrich Hegerl   +11 more
core   +1 more source

Synthesis and Biological Evaluation of 2-Phenoxyacetamide Analogues, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors

Molecules, 2014
Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases ...
Wei Shen, Shian Yu, Jiaming Zhang, Weizheng Jia, Qing Zhu   +4 more
doaj   +1 more source

Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes

Molecules, 2022
Benzylamine is a natural molecule present in food and edible plants, capable of activating hexose uptake and inhibiting lipolysis in human fat cells.
Christian Carpéné, Pénélope Viana, Zsuzsa Iffiú-Soltesz, Pál Tapolcsányi, Anna Ágota Földi, Péter Mátyus, Petra Dunkel   +6 more
doaj   +1 more source

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. [PDF]

PLoS ONE, 2016
Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Chun-Sing Lam, George Lim Tipoe, Johnny Kong-Ching Wong, Moussa B H Youdim, Man-Lung Fung   +4 more
doaj   +1 more source

Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo

Molecules, 2023
Amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of Alzheimer’s disease (AD).
Yi Chen
doaj   +1 more source

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]

, 2014
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Bautista-Aguilera, O.M., Marco-Contelles, J., Filipić, Slavica, Filipic, S., Yañez, M., Andrés, Lucía de, Yáñez, Matilde, Samadi, A., Chioua, Mourad, de Andres, Lucia, Ramsay, R. R., Alcaro, Stefano, Samadi, Abdelouahid, Alcaro, S., Rodríguez-Franco, María Isabel, Rodríguez-Franco, M.I., Nikolić, Katarina, Agbaba, Danica, Soriano, Elena, Agbaba, D., Isabel Rodriguez-Franco, Maria, Ortuso, Francesco, Ramsay, R.R., Chioua, M., Marco-Contelles, José, Ortuso, F., Soriano, E., Ramsay, Rona R., Nikolic, K., De Andrés, L., Bautista-Aguilera, Óscar M.   +30 more
core   +1 more source

Development of Novel Fluorine-18 Labeled PET Radioligands for Monoamine Oxidase B (MAO-B) [PDF]

, 2013
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and ...
Nag, Sangram
core   +1 more source

Towards the directed evolution of an L-aspartate oxidase from Pseudomonas putida [PDF]

, 2012
Amino acid oxidases (AAOs) are enantioselective flavoenzymes that catalyse the oxidation of amino acids into imino acids, which spontaneously hydrolyse in water to form keto acids. AAOs have several potential applications, most notably as biocatalysts in
Leese, Charlotte
core   +6 more sources