Results 161 to 170 of about 715,660 (339)

Triton X-114 phase fractionation of an integral membrane surface protein mediating monoclonal antibody killing of Mycoplasma hyorhinis [PDF]

, 1987
Harold Riethman, Mireille Boyer, Kim S. Wise   +2 more
openalex   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Monoclonal Antibodies-A New Horizon in Alzheimer's Treatment. [PDF]

J Clin Neurol
Kwon HS, Koh SH.
europepmc   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

The Benefits and Safety of Monoclonal Antibodies: Implications for Cancer Immunotherapy. [PDF]

J Inflamm Res
Zhang S, Chen W, Zhou J, Liang Q, Zhang Y, Su M, Zhang Z, Qu J.   +7 more
europepmc   +1 more source

Molecular specificities of monoclonal antibodies directed against virulent Treponema pallidum [PDF]

, 1986
K S Marchitto, C K Selland-Grossling, Michael V. Norgard   +2 more
openalex   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Clinical trials of broadly neutralizing monoclonal antibodies in people living with HIV - a review. [PDF]

AIDS Res Ther
Mahomed S, Pillay K, Hassan-Moosa R, Galvão BPGV, Burgers WA, Moore PL, Rose-Abrahams M, Williamson C, Garrett N.   +8 more
europepmc   +1 more source

USE OF MONOCLONAL ANTIBODIES IN ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA) FOR DETECTION OF BOTULINUM TYPE B TOXINS

, 1984
Serv eacute NOTERMANS, Shunji Kozaki, Yoichi Kamata, Genji Sakaguchi   +3 more
openalex   +2 more sources

A target structure for a series of human cloned natural killer cell lines is recognized by both anti-TNKtar and 4F2 monoclonal antibodies. [PDF]

, 1985
Philippe Moingeon, Alexandre E. Nowill, G. Courtois, Bruno Azzarone, P Motte, A. Ythier, Claude Bohuon, Thierry Hercend   +7 more
openalex   +1 more source