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Deimmunization of Monoclonal Antibodies
2008Immunogenicity is a major limitation to therapy with certain monoclonal antibodies and proteins. A major driver for immunogenicity is the presence of human T-cell epitopes within the protein sequence which can activate helper T-cells resulting in the sustained production of antibodies and neutralization of the therapeutic effect.
Laura J. Crompton +3 more
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Monoclonal antibodies in haematology
Blood Reviews, 1989The development of methods for the production of monoclonal antibodies is having an important impact in the field of immunohaematology. Four separate areas are implicated. First, there is the use of monoclonal antibodies in blood transfusion, where antibodies within the ABO, Rh, Lewis, P, MN, Kell and Lutheran systems are available.
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Radiolabeling of Monoclonal Antibodies
2000Radiolabeling of monoclonal antibodies (mAbs) is often one of the principal methods for the in vitro and in vivo assessment of these reagents, whether this is determining the affinity of a new reagent, preparing for preclinical testing, or clinically for diagnostic or therapeutic use.
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Monoclonal Antibody TfR Monoclonal Antibody
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017openaire +2 more sources
Monoclonal antibodies in cancer immunotherapy
Molecular Biology Reports, 2018Ilgin Kimiz-Gebologlu +2 more
semanticscholar +1 more source
Monoclonal Antibodies for Emerging Infectious Diseases - Borrowing from History.
New England Journal of Medicine, 2018Hilary D. Marston +2 more
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Monoclonal antibodies in oncology
La Ricerca in Clinica e in Laboratorio, 1984Colnaghi MI +5 more
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