Results 41 to 50 of about 2,198,135 (358)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Improving product quality and productivity of an antibody-based biotherapeutic using inverted frustoconical shaking bioreactors

Frontiers in Bioengineering and Biotechnology
The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs).
Xuekun Wang, Xuekun Wang, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Zhenhua Li, Zhenhua Li, Zhenhua Li, Jiawei Cao, Jiawei Cao, Jiawei Cao, Rongrong Fu, Rongrong Fu, Mengjiao Xu, Mengjiao Xu, Xiang Zhao, Xiang Zhao, Fugui Wang, Fugui Wang, Xinmeng Zhang, Taimin Dong, Xu Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Shen Hou, Shen Hou, Shen Hou, Lusha Ji, Lusha Ji, Lusha Ji, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo   +41 more
doaj   +1 more source

Characterization of Norwalk virus GI specific monoclonal antibodies generated against Escherichia coli expressed capsid protein and the reactivity of two broadly reactive monoclonal antibodies generated against GII capsid towards GI recombinant fragments

BMC Microbiology, 2001
Background Norwalk virus causes outbreaks of acute non-bacterial gastroenteritis in humans. The virus capsid is composed of a single 60 kDa protein. In a previous study, the capsid protein of recombinant Norwalk virus genogroup II was expressed in an E ...
Takino Koichi, Utagawa Etsuko, Kawamoto Hiroyoshi, Kuzuguchi Tsuyoshi, Oishi Isao, Yamazaki Kenji, Suzuki Yasuhiko, Terano Yoshitake, Yoda Tomoko, Oda Hajime, Shibata Tadayoshi   +10 more
doaj   +1 more source

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

Nature Communications, 2016
Cancer cells express tumour-specific antigens derived via genetic and epigenetic alterations, which may be targeted by T-cell-mediated immune responses.
Ju Yeon Lee, Hyun Tae Lee, Woori Shin, Jong-Kun Chae, Jaehyuk Choi, Sung Hyun Kim, Heejin Lim, Tae Won Heo, Kyeong Young Park, Yeon Ji Lee, S. Ryu, J. Son, Jee Un Lee, Y. Heo   +13 more
semanticscholar   +1 more source

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

bioRxiv, 2021
Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis for COVID-19. However, ongoing evolution of SARS-CoV-2 can render monoclonal antibodies ineffective.
Tyler N. Starr, Allison J. Greaney, A. Dingens, J. Bloom   +3 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Methodological validation study of nrCE-SDS for monoclonal antibodies

生物医学转化
Objective To perform methodological validation of non-reduced capillary electrophoresis-sodium dodecyl sulfate (nrCE-SDS) for monoclonal antibodies, providing a reference for the methodological validation of corresponding quality control methods in the ...
Xu Gangling, Ni Yongbo, Wu Gang, Fu Zhihao, Yu Chuanfei, Wang Lan   +5 more
doaj   +1 more source

Fixed Dosing of Monoclonal Antibodies in Oncology

The Oncologist, 2017
In the field of oncology, most drugs are administered in a body–size‐based dosing schedule instead of a fixed dose for all patients. This article presents the advantages of fixed dosing of monoclonal antibodies, arguing in favor of fixed dosing schemes ...
J. Hendrikx, J. Haanen, E. Voest, J. Schellens, A. Huitema, J. Beijnen   +5 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

Protein & Cell, 2017
There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling.
Liming Liu
semanticscholar   +1 more source