Results 51 to 60 of about 1,044,682 (307)

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco [PDF]

, 2014
The proposed clinical trial in Africa of VRC01, a potent broadly neutralizing antibody (bNAb) capable of neutralizing 91% of known HIV-1 isolates, raises concerns about testing a treatment which will be too expensive to be accessible by the most ...
EMEA, Montefiori D.C., Pabst M., Pegu A., WHO   +4 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Dataset and AI Workflow for Deep Learning Image Classification of Ulcerative Colitis and Colorectal Cancer

Data
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by the deregulation of immuno-oncology markers. IBD includes ulcerative colitis and Crohn’s disease.
Joaquim Carreras, Giovanna Roncador, Rifat Hamoudi   +2 more
doaj   +1 more source

Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled [PDF]

, 1982
Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative ...
C. J. Kreo, C. N. Baxevanis, C. N. Baxevanis, D. L. Longo, E. A. Lerner, E. M. Shevach, G. Corradin, H. Lemke, H. O. McDevitt, H. O. McDevitt, J. Sprent, J. T. Nepom, Jan Klein, K. Ozato, L.P. Ryder, M. Shigeta, Matko Marušić, N. Ishii, P. C. Dubriel, P. P. Jones, R. H. Schwartz, R. M. Zinkernagel, U. K. Laemmli, U. Koszinowski, Ulrich Koszinowski, V. T. Oi, Y. Hosaka, Z. A. Nagy, Zoltan A. Nagy   +28 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics

International Journal of Pharmaceutics: X
The development of high-concentration monoclonal antibody (mAb) formulations for subcutaneous administration is faces critical stability challenges, particularly oxidation and aggregation, which compromise efficacy and safety.
Xuekun Wang, Xinyu Zhang, Jin Xu, Shuhai Xu, Keyuan Huang, Qiaoling Ni, Xinyi Shen, Weitao Zhang, Tao Liu, Taimin Dong, Dan Mao, Chunguang Zheng, Wei Yu, Qingcheng Guo, Zhixin Li, Jiawei Cao, Fubo Han, Lusha Ji, Weizhu Qian, Sheng Hou, Jun Li, Ziqiao Sun, Jianxin Dai, Yajun Guo, Dapeng Zhang, Huaizu Guo   +25 more
doaj   +1 more source

Data on the characterization of follicle-stimulating hormone monoclonal antibodies and localization in Japanese eel pituitary

Data in Brief, 2016
Monoclonal antibodies were generated against recombinant follicle-stimulating hormone (rec-FSH) from Japanese eel Anguilla japonica; rec-FSH was produced in Escherichia coli and purified using Ni-NTA Sepharose column chromatography.In support of our ...
Dae-Jung Kim, Chae-Won Park, Munkhzaya Byambaragchaa, Shin-Kwon Kim, Bae-Ik Lee, Hyung-Kyu Hwang, Jeong-In Myeong, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min   +9 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Monoclonal antibodies reactive with swine lymphocytes [PDF]

, 1984
A panel of monoclonal antibodies (mAb) with specificity for swine leukocytes was prepared by somatic cell hybridization with the use of spleen cells from mice immunized with swine thymocytes.
Jonjic, Stipan, Koszinowski, Ulrich H.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source