Results 51 to 60 of about 759,990 (316)

Methods for radiolabelling of monoclonal antibodies

, 2013
The use of radionuclide labels allows to study the pharmacokinetics of monoclonal antibodies, to control the specificity of their targeting and to monitor the response to an antibody treatment with high accuracy.
Andersson, Karl, Andersson, Karl,, Orlova, Anna, Vladimir Tolmachev, Orlova, Anna,, Tolmachev, Vladimir, Anna Orlova, Karl Andersson, Tolmachev, Vladimir,   +8 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics

International Journal of Pharmaceutics: X
The development of high-concentration monoclonal antibody (mAb) formulations for subcutaneous administration is faces critical stability challenges, particularly oxidation and aggregation, which compromise efficacy and safety.
Xuekun Wang, Xinyu Zhang, Jin Xu, Shuhai Xu, Keyuan Huang, Qiaoling Ni, Xinyi Shen, Weitao Zhang, Tao Liu, Taimin Dong, Dan Mao, Chunguang Zheng, Wei Yu, Qingcheng Guo, Zhixin Li, Jiawei Cao, Fubo Han, Lusha Ji, Weizhu Qian, Sheng Hou, Jun Li, Ziqiao Sun, Jianxin Dai, Yajun Guo, Dapeng Zhang, Huaizu Guo   +25 more
doaj   +1 more source

Data on the characterization of follicle-stimulating hormone monoclonal antibodies and localization in Japanese eel pituitary

Data in Brief, 2016
Monoclonal antibodies were generated against recombinant follicle-stimulating hormone (rec-FSH) from Japanese eel Anguilla japonica; rec-FSH was produced in Escherichia coli and purified using Ni-NTA Sepharose column chromatography.In support of our ...
Dae-Jung Kim, Chae-Won Park, Munkhzaya Byambaragchaa, Shin-Kwon Kim, Bae-Ik Lee, Hyung-Kyu Hwang, Jeong-In Myeong, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min   +9 more
doaj   +1 more source

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Immunotoxicity of monoclonal antibodies [PDF]

mAbs, 2009
Monoclonal antibodies (mAbs) are large molecules intended to bind to specific targets often expressed on the immune system, and to treat various immunopathological conditions. Therefore, mAbs can be considered to have a high potential for immunotoxicity, which is reflected in the clinical experience accumulated on mAbs-induced adverse effects related ...
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

MONOCLONAL ANTIBODIES

Hematology, Transfusion and Cell Therapy
Obinutuzumab, an anti CD-20 monoclonal antibody, can be used in combination with venetoclax, ibrutinib or acalabrutinib in CLL patients with newly diagnosed or relaps patient's treatment indications. Another anti CD-20 monoclonal antibody, rituximab, has
Zekeriya Aksöz
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source