Results 41 to 50 of about 762,085 (316)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Monoclonal Antibodies to Migraine: Witnesses to modern biomedicine, an A-Z [PDF]

, 2014
The History of Modern Biomedicine Research Group hosted its first Witness Seminar, on monoclonal antibodies, in 1993. Since then more than sixty such meetings have been held, the most recent on migraine in 2013.
Tansey, EM
core  

Human Monoclonal Antibodies Humoral Immune Response in Patients with Cancer [PDF]

The monoclonal antibody technology has had a major impact on the serological and biochemical analysis of human tumor antigens. Monoclonal antibodies have rapidly led to the identification and characterization of a large number of antigenic determinants ...
Houghton, Alan N, Cote, Richard J
core   +1 more source

Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies [PDF]

, 2018
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq: 425535/2016-9We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI).
Andrei Moroz, Julia Paiola da Silva, Da Silva, Julia Paiola [UNESP], Fusco-Almeida, Ana Marisa, Elenice Deffune, Da Silva, Julia Paiola, De Lima Fontes, Marina, Moroz, Andrei [UNESP], De Lima Fontes, Marina [UNESP], Marina de Lima Fontes, Nakamura, Cecília Naomi, Deffune, Elenice [UNESP], Cecília Naomi Nakamura, Deffune, Elenice, Matheus Bertanha, Bertanha, Matheus [UNESP], Ana Marisa Fusco-Almeida, Moroz, Andrei, Fusco-Almeida, Ana Marisa [UNESP], Nakamura, Cecília Naomi [UNESP], De Almeida, Rodrigo [UNESP], Bertanha, Matheus, De Almeida, Rodrigo, Rodrigo de Almeida   +23 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving product quality and productivity of an antibody-based biotherapeutic using inverted frustoconical shaking bioreactors

Frontiers in Bioengineering and Biotechnology
The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs).
Xuekun Wang, Xuekun Wang, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Zhenhua Li, Zhenhua Li, Zhenhua Li, Jiawei Cao, Jiawei Cao, Jiawei Cao, Rongrong Fu, Rongrong Fu, Mengjiao Xu, Mengjiao Xu, Xiang Zhao, Xiang Zhao, Fugui Wang, Fugui Wang, Xinmeng Zhang, Taimin Dong, Xu Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Shen Hou, Shen Hou, Shen Hou, Lusha Ji, Lusha Ji, Lusha Ji, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo   +41 more
doaj   +1 more source

Monoclonal Antibodies as Immune Modulators for Cancer Therapy

Canadian Journal of Infectious Diseases, 1992
Monoclonal antibodies may modulate immune and/or biological responses alone, or as carriers of specific agents. Monoclonal antibodies directed against tumours may be indirectly cytotoxic by modulation of antibody-dependent, cell-mediated cytotoxicity or ...
Robert O Dillman
doaj   +1 more source

Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces [PDF]

, 1989
Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens.
Eichhorn, Werner, Czerny, C. P.
core  

Serological Dissection of Human Breast Cancer with Mouse and Human Monoclonal Antibodies [PDF]

Over the past two years our group has taken two distinct approaches in the study of breast cancer: The first is the definition of the antigenic phenotype of breast cancer using mouse monoclonal antibodies as serological probes.
Old, L. J, Oettgen, H. F, Morrissey, D, Cote, R. J, Thomson, T. M, Houghton, A. N, Cordon-Cardo, C   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source