Leveraging Large Language Models to Predict Antibody Biological Activity Against Influenza A Hemagglutinin [PDF]
arXivMonoclonal antibodies (mAbs) represent one of the most prevalent FDA-approved modalities for treating autoimmune diseases, infectious diseases, and cancers. However, discovery and development of therapeutic antibodies remains a time-consuming and expensive process. Recent advancements in machine learning (ML) and artificial intelligence (AI) have shown
arxiv
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, EarlyView.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source
F(ab')2 fragments of anti-Mo1 (904) monoclonal antibodies do not prevent myocardial stunning. [PDF]
, 1989 Robert J. Schott +6 more
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Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Hyperbox Mixture Regression for Process Performance Prediction in Antibody Production [PDF]
arXivThis paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data's complexity and high dimensionality.
arxiv
Using QCM‐D for Real‐Time Analysis of Cell Adhesion Dynamics at Biointerfaces
Advanced Materials Interfaces, EarlyView.This study explores adhesion of human fibroblasts to functionalized biomaterial surfaces. Quartz crystal microbalance with dissipation (QCM‐D) is used to measure cell responses in real time. The QCM‐D signalis correlated with changes in cell morphology and focal adhesion kinase (FAK) activation. This data shows a positive correlation between the energy
Agnes Rogala +2 more
wiley +1 more source
Monoclonal antibodies against human myelomonocytic cells: detection of certain lineage-specific antigens on CFU-GM progenitor cells. [PDF]
, 1985 Masatoshi Takaishi, Shu Man Fu
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Advanced Materials Interfaces, EarlyView.This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan +2 more
wiley +1 more source
Gut endocrine cell population in coeliac disease estimated by immunocytochemistry using a monoclonal antibody to chromogranin. [PDF]
, 1986 R Pietroletti +9 more
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Advanced Materials Technologies, EarlyView.Non‐faradaic label‐free impedimetric determination of cortisol is demonstrated with gold nanoparticles (AuNP) functionalized laser‐induced graphene interdigitated electrodes (LIG‐IDE). The AuNP functionalized LIG‐IDE exhibits remarkable characteristics including good logarithmic linear range, high reproducibility, repeatability, and robust selectivity.
Kyle Duke +9 more
wiley +1 more source