Results 101 to 110 of about 2,611,580 (432)

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

Plant Biotechnology Journal, 2015
Although plant biotechnology has been widely investigated for the production of clinical-grade monoclonal antibodies, no antibody products derived from transgenic plants have yet been approved by pharmaceutical regulators for clinical testing.
J. Ma, J. Drossard, D. Lewis, F. Altmann, Julia Boyle, P. Christou, T. Cole, P. Dale, C. V. van Dolleweerd, Valerie Isitt, D. Katinger, Martin Lobedan, Hubert Mertens, Mathew J. Paul, T. Rademacher, M. Sack, Penny A C Hundleby, G. Stiegler, E. Stoger, R. Twyman, B. Vcelar, R. Fischer   +21 more
semanticscholar   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Optimization of conditions for gene delivery system based on PEI [PDF]

Nanomedicine Journal, 2017
Objective(s): PEI based nanoparticle (NP) due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells.
Roya Cheraghi, Mohsen Alipour, Mahboobeh Nazari, Saman Hosseinkhani   +3 more
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Development of a visual Adhesion/Invasion Inhibition Assay to assess the functionality of Shigella-specific antibodies

Frontiers in Immunology
IntroductionShigella is the etiologic agent of a bacillary dysentery known as shigellosis, which causes millions of infections and thousands of deaths worldwide each year due to Shigella’s unique lifestyle within intestinal epithelial cells.
Giampiero Batani, Giacomo Vezzani, Sabrina Lashchuk, Abdelmounaaim Allaoui, Dario Cardamone, Maria Michelina Raso, Elena Boero, Emanuele Roscioli, Matteo Ridelfi, Gianmarco Gasperini, Mariagrazia Pizza, Omar Rossi, Francesco Berlanda Scorza, Francesca Micoli, Rino Rappuoli, Claudia Sala   +15 more
doaj   +1 more source

How is the Monoclonal Antibodies Kinetic Affected by Changes of Their Physical Parameters? [PDF]

arXiv, 2010
The study of monoclonal antibodies (MAb) is a field of great interest to science medicine, for example, anti-TNF agents (infliximab and adalimumab) represent an important tool for the management of autoimmune and inflammatory disorders. In this work we focus on the physical description of the transport kinetics of MAb in a fluid with laminar flow and ...
arxiv  

Engineering a Molecular Missile for Pancreatic Cancer Detection: Vector Design [PDF]

, 2018
Pancreatic cancer, though rare, is expected to be the second-leading cause of cancer-related death by 2030 (Rahib et al., 2014). CA 19-9 is currently the most widely used biomarker for pancreatic cancer detection, but detection of CA 19-9 relies on the ...
Castillo, Sophia, Zhang, Zhiwen
core   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Topological AI forecasting of future dominating viral variants [PDF]

SIAM 2022, 2022
The understanding of the mechanisms of SARS-CoV-2 evolution and transmission is one of the greatest challenges of our time. By integrating artificial intelligence (AI), viral genomes isolated from patients, tens of thousands of mutational data, biophysics, bioinformatics, and algebraic topology, the SARS-CoV-2 evolution was revealed to be governed by ...
arxiv