Results 81 to 90 of about 801,490 (249)

Monoclonal antibodies against Pseudomonas aeruginosa elastase: A neutralizing antibody which recognizes a conformational epitope related to an active site of elastase [PDF]

, 1992
Shin‐ichi Yokota, Hiroshi Ohtsuka, Hiroshi Noguchi   +2 more
openalex   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Early steroid withdrawal: a niche for anti-interleukin 2 receptor monoclonal antibodies? [PDF]

, 2018
Rachel Hellemans, Jean‐Louis Bosmans, Daniel Abramowicz   +2 more
openalex   +1 more source

Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial [PDF]

, 2023
Magdalena E. Sobieszczyk, Sharon Mannheimer, Carmen A. Paez, Chenchen Yu, Theresa Gamble, Deborah Theodore, Wairimu Chege, Margaret Yacovone, Brett Hanscom, Jack Heptinstall, Kelly E. Seaton, Lily Zhang, Maurine D. Miner, Amanda Eaton, Joshua A. Weiner, Kenneth H. Mayer, Spyros A. Kalams, Kathryn E. Stephenson, Boris Jülg, Marina Caskey, Michel C. Nussenzweig, Lúcio Gama, Dan H. Barouch, Margaret E. Ackerman, Georgia D. Tomaras, Yunda Huang, David C. Montefiori   +26 more
openalex   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Epitope mapping of function‐blocking monoclonal antibody CM6 suggests a “weak” integrin binding site on the laminin‐332 LG2 domain [PDF]

, 2010
Hironobu Yamashita, Meiling Shang, Manisha Tripathi, Jérôme Jourquin, Walter Georgescu, Shanshan Liu, Brandy Weidow, Vito Quaranta   +7 more
openalex   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans

Frontiers in Immunology
ObjectivesThe rapid emergence of SARS-CoV-2 prompted accelerated vaccine development, with neutralization assays serving as essential tools to evaluate vaccine-induced immune responses.MethodsA post-hoc analysis of a Phase I/II trial evaluated the ...
Cuige Gao, Jiang Yi, Adam Baidoo, Dongfang Liu, Jing Li, Dongyang Li, Jian Li, Qiang Zhou, Liangzhi Xie, Liangzhi Xie, Liangzhi Xie   +10 more
doaj   +1 more source

Detection of Common Flagella Antigen in Bacillus cereus by Monoclonal Antibody [PDF]

, 1990
Takeshi Mikami, Kenji Hiraoka, Tomonori Murakami, Jotica Boon‐Long, Tatsuji Matsumoto, Masuko Suzuki   +5 more
openalex   +1 more source