Results 81 to 90 of about 16,555,945 (165)

Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies

Haematologica, 2020
Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease ...
Julio Delgado, Ferran Nadeu, Dolors Colomer, Elias Campo   +3 more
doaj   +1 more source

EHA Guidelines on management of chronic lymphocytic leukemia and Richter transformation

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Previous editions of the European guidelines for the management of chronic lymphocytic leukemia (CLL) were developed by experts in CLL under the auspices of the European Society for Medical Oncology (ESMO). These previous editions have served as a reference text for many physicians caring for patients with CLL.
Barbara Eichhorst, Paolo Ghia, Francesc Bosch, Ruth Clifford, Michael Gregor, Romain Guieze, Arnon P. Kater, Carsten U. Niemann, Sarka Pospisilova, Tadeusz Robak, Anna Schuh, Kostas Stamatopoulos, Tamar Tadmor, Nick York   +13 more
wiley   +1 more source

Image_3_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [PDF]

IntroductionIn monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation.
Sandra Silva (3520043), Helena Matos Silva (18267523), Ignacio Criado (430275), Rodrigues, Cristiana, Domingues, M. Rosário, Ana Catarina Oliveira (18267514), Silva, Isabel, Inês Damásio (18267520), Orfao, Alberto, Almeida, Julia, Ana Teresa Simões (18267517), Sarmento-Ribeiro, Ana Bela, Matos Silva, Helena, Artur Paiva (354292), Aryane Pinho (18267511), Alberto Orfao (108164), Catarina Geraldes (18267529), Urbano, Mafalda, Paula Laranjeira (309219), Mafalda Urbano (18267526), Laranjeira, Paula, Geraldes, Catarina, M. Rosário Domingues (6592847), Coucelo, Margarida, Criado, Ignacio, Silva, Sandra, Isabel Silva (587054), Cristiana Rodrigues (18267508), Simões, Ana Teresa, Paiva, Artur, Julia Almeida (108139), Margarida Coucelo (4318057), Ana Bela Sarmento-Ribeiro (11605969), Pinho, Aryane, Damásio, Inês, Oliveira, Ana C.   +35 more
core   +1 more source

Persistent polyclonal B lymphocytosis with multiple bcl-2/IgH rearrangements: a benign disorder

Haematologica, 1998
The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosis (PPBL), presented in young asymptomatic women with an
E Granados, P Llamas, I Pinilla, JF Tomas, P Font, R Camara, F Olmeda, R Arranz, JM Fernandez-Ranada   +8 more
doaj  

Image_4_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [PDF]

IntroductionIn monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation.
Sandra Silva (3520043), Helena Matos Silva (18267523), Ignacio Criado (430275), Rodrigues, Cristiana, Domingues, M. Rosário, Ana Catarina Oliveira (18267514), Silva, Isabel, Inês Damásio (18267520), Orfao, Alberto, Almeida, Julia, Ana Teresa Simões (18267517), Sarmento-Ribeiro, Ana Bela, Matos Silva, Helena, Artur Paiva (354292), Aryane Pinho (18267511), Alberto Orfao (108164), Catarina Geraldes (18267529), Urbano, Mafalda, Paula Laranjeira (309219), Mafalda Urbano (18267526), Laranjeira, Paula, Geraldes, Catarina, M. Rosário Domingues (6592847), Coucelo, Margarida, Criado, Ignacio, Silva, Sandra, Isabel Silva (587054), Cristiana Rodrigues (18267508), Simões, Ana Teresa, Paiva, Artur, Julia Almeida (108139), Margarida Coucelo (4318057), Ana Bela Sarmento-Ribeiro (11605969), Pinho, Aryane, Damásio, Inês, Oliveira, Ana C.   +35 more
core   +1 more source

The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core   +1 more source

Gene expression analysis after BTK and PI3Kδ inhibitor treatment in chronic lymphocytic leukemia identifies cell‐surface CXCR4 as a synergistic target for combinatorial therapy

HemaSphere, Volume 10, Issue 9, September 2026.
Gabriela Mladonicka Pavlasova, Veronika Sandova, Laura Ondrisova, Vaclav Seda, Petra Pavelkova, Daniel Filip, Krystof Hlavac, Josef Vecera, Sarka Pospisilova, Anna Panovska, Stacey M. Fernandes, Michael Doubek, Jennifer R. Brown, Marek Mraz   +13 more
wiley   +1 more source

Serum levels of B-cell activating factor are associated with a reduced risk of chronic lymphocytic leukemia

Blood Cancer Journal
Impact Immune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell ...
Eleanor Frost, Jonathan N. Hofmann, Wen-Yi Huang, Ashley A. Frazer-Abel, Kevin D. Deane, Sonja I. Berndt   +5 more
doaj   +1 more source

A Unique Hairy Cell Leukemia Variant

Case Reports in Oncology, 2016
A 65-year-old woman presented with easy bruising, left upper quadrant pain, decreased appetite, and weight loss. She had splenomegaly and lymphocytosis (lymphocyte count of 11.6 × 109/l), with remarkably abnormal appearing morphology.
Charles Jian, Cyrus C. Hsia
doaj   +1 more source

Asymptomatic T prolymphocytic leukemia: case report and literature review [PDF]

Einstein (São Paulo)
T-cell prolymphocytic leukemia is a rare and aggressive mature T-cell malignancy that usually presents with marked lymphocytosis, hepatosplenomegaly, lymphadenopathy, and B symptoms.
Luiz Frederico Bezerra Honorato Junior, Elizabeth Xisto Souto, Roberta Maria da Silva Oliveira Safranauskas, Renata Kiyomi Kishimoto, Laiz Cameirao Bento, Marilia Sandoval Passaro, Rodrigo Seiti Kojima, Nydia Strachman Bacal, Barbara Ferreira Cordeiro Galvão, Luiz Gustavo Ferreira Cortês, Elvira Deolinda Rodrigues Pereira Velloso, Nelson Hamershlak   +11 more
doaj   +1 more source