Results 91 to 100 of about 193,762 (235)

Monoclonal gammopathy of clinical significance in a young patient treated with melphalan‐thalidomide‐prednisone

Clinical Case Reports
Key Clinical Message We report an observation of a young patient presenting with severe type 1 cryoglobulinemic vasculitis revealing a monoclonal gammopathy of clinical significant.
Oliva Henintsoa Rakotonirainy, Lalao Nomenjanahary Rakotonirina, Stevy Desana, Lauréat Brunda Manahandray, Rajo Païdia Radinasoa, Tahinasoa Randriamampianina, Fahafahantsoa Rapelanoro Rabenja   +6 more
doaj   +1 more source

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

Haematologica, 2017
Monoclonal gammopathy of undetermined significance is a pre-malignant precursor of multiple myeloma with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations ...
Aneta Mikulasova, Christopher P. Wardell, Alexander Murison, Eileen M. Boyle, Graham H. Jackson, Jan Smetana, Zuzana Kufova, Ludek Pour, Viera Sandecka, Martina Almasi, Pavla Vsianska, Evzen Gregora, Petr Kuglik, Roman Hajek, Faith E. Davies, Gareth J. Morgan, Brian A. Walker   +16 more
doaj   +1 more source

PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017
Monoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or ...
A. A. Yakovlev, E. S. Tarabanova, A. G. Smochilin, R. A. Gapeshin, M. V. Yakovleva   +4 more
doaj   +1 more source

Early‐Life Exposures and Risk of Multiple Myeloma: A Population‐Based Case–Control Study in Australia

International Journal of Cancer, Volume 159, Issue 7, Page 1697-1706, 1 October 2026.
Early‐life exposures may influence immune system development and, in turn, affect cancer susceptibility. In this population‐based case‐control study, the authors examined whether in utero or early childhood exposures were associated with the risk of developing multiple myeloma in adulthood.
Zhuoyu Sun, Julie K. Bassett, Simon Cheah, Fiona J. Bruinsma, Wendy Cozen, Simon J. Harrison, H. Miles Prince, Nicole Wong Doo, Graham G. Giles, Roger L. Milne, Brigid M. Lynch   +10 more
wiley   +1 more source

Myeloma‐Associated Sporadic Late‐Onset Nemaline Myopathy, Successfully Treated with Daratumumab Based Induction and Autologous Stem Cell Transplantation: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Sporadic late‐onset nemaline myopathy (SLONM) is a rare, acquired myopathy often associated with monoclonal gammopathy. We report a 48‐year‐old man presenting with progressive proximal and truncal muscle weakness in whom SLONM associated with smoldering myeloma was highly suspected.
Kenji Moriwaki, Yawara Kawano, Makoto Nakajima, Nao Nishimura, Mitsuharu Ueda, Jun‐ichirou Yasunaga   +5 more
wiley   +1 more source

Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy

, 2006
Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied V(H)DJ(H) and V(L)J(L) gene use
Notermans, Nicolette C., Lokhorst, Henk M., Marijke Eurelings, Henk M. Lokhorst, Bloem, Andries C., Eurelings, Marijke, Andries C. Bloem, Nicolette C. Notermans, Berris van Kessel, John H.J. Wokke, Surinder S. Sahota, Wokke, John H.J., Jacobs, Bart C., Bart C. Jacobs, van Kessel, Berris, Sahota, Surinder S.   +15 more
core   +1 more source

Primary Amyloidosis and a Case Report

مجله دانشکده پزشکی اصفهان, 2009
Background: Primary amyloidosis is the most common form of systemic Amyloidosis. Amyloidosis is the results of fibril formation due to plasma cell dyscrasia or rarely monoclonal gammopathy of uncertain significance (MGUS).
Hasan Vosoghinia, Maryam Sahebari, Masoumeh Salari, Afsoon Fazlinejad   +3 more
doaj  

Management of Patients With Hepatitis C Virus, Monoclonal Gammopathy of Undetermined Significance, and Multiple Myeloma

Journal of Investigative Medicine High Impact Case Reports, 2017
Background and Aim: The vast majority of the 2.7 million individuals in the United States who are currently infected with hepatitis C virus (HCV) were born between 1945 and 1965.
Alisse Hannaford BS, David Del Bello MD, Siyang Leng MD, Ajai Chari MD, PhD, Ponni Perumalswami MD, Douglas Dieterich MD, Andrea Branch PhD   +6 more
doaj   +1 more source

Molecular Characterization of Mobilized Apheresis Hematopoietic Progenitor Cells Designated for Autologous Stem Cell Transplantation in Multiple Myeloma

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Multiple myeloma is the second most common malignancy of the lymphoid system and accounts for about 2% of cancer deaths. Treatment generally consists of chemotherapy and autologous stem cell transplantation. Clinical trial results are equivocal as to whether autologous stem cell transplantation in the treatment of multiple myeloma
Gurmukh Singh, Kiana Kim, Roni J. Bollag
wiley   +1 more source

Repeated Response to Daratumumab in Refractory MGUS‐Associated Pure Red Cell Aplasia Persisting After Allogeneic Transplantation: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Pure red cell aplasia (PRCA) is usually managed as a disorder driven predominantly by cellular immune mechanisms, but plasma cell‐directed therapy may be relevant in selected cases associated with monoclonal gammopathy. We report a case of refractory PRCA associated with IgG‐kappa monoclonal gammopathy of undetermined significance (MGUS). A 64‐
Kyoko Yoshihara, Toshimitsu Matsui, Ikuo Matsuda, Mami Samori, Yoshiyuki Fujita, Saki Takahashi, Fuyuki Yamagata, Nobuto Utsunomiya, Chisato Ohe, Satoshi Yoshihara   +9 more
wiley   +1 more source